en تخصصي Special مقالات اصيل Original Article <span style="font-size:12pt"><span style="line-height:150%"><span style="text-autospace:none"><span style="font-family:&quot;Times New Roman&quot;,serif"><b>Background: </b>Second-degree burns are among the most common cutaneous injuries, and appropriate wound dressing plays a critical role in accelerating healing, reducing pain, and improving clinical outcomes. We aimed to compare the therapeutic efficacy of Alloderm and Agi coat dressings in patients with second-degree burns not requiring skin grafting.</span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:150%"><span style="text-autospace:none"><span style="font-family:&quot;Times New Roman&quot;,serif"><b>Methods: </b>In this double-blind randomized clinical trial, 40 patients with second-degree burns admitted to Taleghani Hospital, Ahvaz, Iran, in 2025 were randomly enrolled to receive either Agi coat or Alloderm dressing. Pain intensity during dressing changes was assessed on days 4, 8, and 16 using the Visual Analog Scale (VAS). Wound healing rate, incidence of infection, duration to complete epithelialization, scar severity based on the Vancouver Scar Scale (VSS), and length of hospital stay were compared between the two groups.<b><span style="font-size:14.0pt"><span style="line-height:150%"></span></span></b></span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:150%"><span style="text-autospace:none"><span style="font-family:&quot;Times New Roman&quot;,serif"><b><span style="font-size:14.0pt"><span style="line-height:150%">Results:</span></span></b> No significant difference was observed in the mean total burn surface area between the Agi coat and Alloderm groups (29.5% vs. 27.84%, <i>P</i>=0.07). Patients treated with Alloderm had a significantly shorter hospital stay compared with the Agi coat group (12.28 &plusmn; 2.49 vs. 16.70 &plusmn; 3.33 days, <i>P</i>=0.04). Pain scores were significantly lower in the Alloderm group on both day 4 (4.02 &plusmn; 2.30 vs. 6.36 &plusmn; 1.87, <i>P</i><0.001) and day 8 (1.14 &plusmn; 1.21 vs. 2.82 &plusmn; 1.20, <i>P</i><0.001). Complete epithelialization occurred faster in the Alloderm group (13.64 &plusmn; 3.16 vs. 16.04 &plusmn; 3.75 days, <i>P</i>=0.001). However, scar severity was significantly lower in the Agi coat group according to VSS scores (<i>P</i><0.001). Infection rates were comparable between groups (<i>P</i>=0.372).<b><span style="font-size:14.0pt"><span style="line-height:150%"></span></span></b></span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:150%"><span style="text-autospace:none"><span style="font-family:&quot;Times New Roman&quot;,serif"><b>Conclusion: </b>Alloderm dressing was associated with reduced pain, accelerated wound healing, and shorter hospitalization in second-degree burn patients, whereas Agi coat demonstrated superior scar quality outcomes.<b><span style="font-size:14.0pt"><span style="line-height:150%"></span></span></b></span></span></span></span><br> &nbsp; Second-degree burn, Alloderm, Agi coat, epithelialization, scar formation, Vancouver Scar Scale 0 0 http://wjps.ir/browse.php?a_code=A-10-1207-2&slc_lang=en&sid=1 Jafar Jafarzadeh drj.jafarzadeh1983@gmail.com 100319475328460017994 100319475328460017994 Yes Department of Plastic Surgery, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Roozbeh Rahbar 100319475328460017995 100319475328460017995 No Department of Plastic Surgery, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Elham Farhadi 100319475328460017996 100319475328460017996 No Clinical Research Development Unit, Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Hashmatullah Khadivipour 100319475328460017997 100319475328460017997 No Department of Plastic Surgery, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran