en تخصصي Special مقالات اصيل Original Article Pyoderma gangrenosum (PG) is a rare inflammatory neutrophilic dermatosis, characterized by painful ulcerative, bullous, or pustular skin conditions. Pathergy is usually used to describe PG which refers to initiation or exacerbation of the disease after accidental or iatrogenic skin trauma. Diagnosis of postoperative PG is challenging not only due to its presentation mimics infectious wounds, but also because there are no standard laboratory parameters for diagnosis. Herein, we present a case of a 46-year-old female patient who had recurrent bilateral breast wound erythema, swelling, pain and necrosis after breast reduction mammoplasty at Centro Hospitalar Conde São Januário Macau SAR in 2018. We diagnosed her postoperative PG and successfully treated her with oral prednisolone with significant therapy response. Pyoderma gangrenosum, Mammoplasty, Breast reduction 103 106 http://wjps.ir/browse.php?a_code=A-10-588-2&slc_lang=en&sid=1 Chun Wa Fong 100319475328460010650 100319475328460010650 Yes 1. Department of Plastic and Reconstruc-tive Surgery, Centro Hospitalar Conde São Januário, Macau SAR Sut Sin Tong 100319475328460010651 100319475328460010651 No 1. Department of Plastic and Reconstruc-tive Surgery, Centro Hospitalar Conde São Januário, Macau SAR Yun Fee Lai 100319475328460010652 100319475328460010652 No 1. Department of Plastic and Reconstruc-tive Surgery, Centro Hospitalar Conde São Januário, Macau SAR