Volume 3, Issue 1 (2014)
WJPS 2014, 3(1): 3-7 |
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Mohsen Hosseinkhani1 
, Davood Mehrabani2 , Mohammad Hassan Karimfar3 , Salar Bakhtiyari4 , Amir Manafi5 , Reza Shirazi 6
, Davood Mehrabani2 , Mohammad Hassan Karimfar3 , Salar Bakhtiyari4 , Amir Manafi5 , Reza Shirazi 6
1- Department of Anatomical Sciences, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran
2- Stem Cell and Transgenic Technology Research Center, Department of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran
3- Department of Anatomical Sciences, School of Medicine, Zahedan University of Medical sciences, Zahedan, Iran
4- Department of Clinical Biochemistry, School of Medicine, Ilam University of Medical sciences, Ilam, Iran
5- Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran
6- Nanobiotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran , r_shirazi@razi.tums.ac.ir
2- Stem Cell and Transgenic Technology Research Center, Department of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran
3- Department of Anatomical Sciences, School of Medicine, Zahedan University of Medical sciences, Zahedan, Iran
4- Department of Clinical Biochemistry, School of Medicine, Ilam University of Medical sciences, Ilam, Iran
5- Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran
6- Nanobiotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran , r_shirazi@razi.tums.ac.ir
Abstract: (9343 Views)
Stem cells are self-renewing cells that can be differentiated into other cell types. Conventional in vitro models for studying stem cells differentiation are usually preformed in two-dimensional (2D) cultures. The design of three-dimensional (3D) in vitro models which ideally are supposed to mimic the in vivo stem cells microenvironment is potentially useful for inducing stem cell derived tissue formation. Biodegradable scaffolds play an important role in creating a 3D environment to induce tissue formation. The application of scaffolding materials together with stem cell technologies are believed to hold enormous potential for tissue regeneration. In this review, we provide an overview of application of tissue engineered scaffolds and stem cells for the development of stem cell-based engineered tissue replacements. In particular, we focus on bone marrow stem cells (BMSCs) and mesenchymal stem cell (MSCs) due to their extensive clinical applications.
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