Volume 15, Issue 1 (2026)
WJPS 2026, 15(1): 80-89 |
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Sara Pilehvar1 
, Ashkan Golabkesh Afshar1 , Saleh Dadmehr1 , Alireza Shirzadeh1 , Shayan Yousefi2 , Sahand Samieirad *3
, Ashkan Golabkesh Afshar1 , Saleh Dadmehr1 , Alireza Shirzadeh1 , Shayan Yousefi2 , Sahand Samieirad *3
1- 1. Department of Oral & Maxillofacial Surgery, faculty of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran
2- 2. Student Research Committee, Faculty of Dentistry, Mashhad University of Medical Sciences, Iran
3- 1. Department of Oral & Maxillofacial Surgery, faculty of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran ,Samieerads@mums.ac.ir
2- 2. Student Research Committee, Faculty of Dentistry, Mashhad University of Medical Sciences, Iran
3- 1. Department of Oral & Maxillofacial Surgery, faculty of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran ,
Abstract: (1461 Views)
The rare odontogenic tumor known as ameloblastoma presents serious problems for kids because of its aggressive nature and capacity to hinder development and function. In order to maximize results, the mural subtype of unicystic ameloblastoma necessitates precision surgical intervention and creative restorative techniques. A 12-year-old girl who presented with discomfort, swelling, and tenderness in her left mandible is described in this report. The patient was admitted to Velayat Hospital in Mashhad, Iran, in 2024 and received the necessary medical treatment there. Histopathological and radiographic analysis verified mural ameloblastoma. A segmental resection of the mandible was part of the treatment, with an emphasis on protecting vital anatomical features including the inferior alveolar nerve and periosteum. Allograft and xenograft materials were applied after a prefabricated plate was used to accomplish reconstruction. Frequent radiography follow-ups showed excellent mandibular continuity restoration and spontaneous bone regeneration. Occlusal modifications boosted functional outcomes, guaranteeing both functional and aesthetic rehabilitation. This example emphasizes the value of a customized strategy in the treatment of pediatric ameloblastoma, stressing the need to strike a balance between growth preservation and efficient tumor eradication. The treatment addressed the aggressive character of the tumor while reducing the chance of recurrence by combining precise surgical procedures with cutting-edge reconstructive strategies. Results were further improved by the use of adaptive dental measures and the preservation of important components. Managing pediatric ameloblastoma requires a customized, multidisciplinary treatment plan. This case demonstrates the efficacy of combining radical and conservative procedures to provide long-term growth, functional restoration, and minimal recurrence risk. Early diagnosis, meticulous surgical planning, and continuous postoperative monitoring enabled the positive results.
Keywords: Ameloblastoma, Segmental Resection, Mandibular Reconstruction, Bone Regeneration, Case report
References
1. Effiom OA, Ogundana OM, Akinshipo AO, Akintoye SO. Ameloblastoma: current etiopathological concepts and management. Oral Dis 2018 Apr;24(3):307-16. [DOI:10.1111/odi.12646]
2. McClary AC, West RB, McClary AC, et al. Ameloblastoma: a clinical review and trends in management. Eur Arch Otorhinolaryngol 2016 Jul;273(7):1649-61. [DOI:10.1007/s00405-015-3631-8]
3. Fuchigami T, Ono Y, Kishida S, Nakamura N. Molecular biological findings of ameloblastoma. Jpn Dent Sci Rev 2021 Nov;57:27-32. [DOI:10.1016/j.jdsr.2020.12.003]
4. Kreppel M, Zöller J. Ameloblastoma-Clinical, radiological, and therapeutic findings. Oral Dis 2018 Mar;24(1-2):63-6. [DOI:10.1111/odi.12702]
5. Masthan KM, Anitha N, Krupaa J, Manikkam S. Ameloblastoma. J Pharm Bioallied Sci 2015 Apr;7(Suppl 1):S167-70. [DOI:10.4103/0975-7406.155891]
6. Pandiar D, Anand R, Kamboj M, Narwal A, Shameena PM, Devi A. Metastasizing Ameloblastoma: A 10 Year Clinicopathological Review with an Insight Into Pathogenesis. Head Neck Pathol 2021 Sep;15(3):967-74. [DOI:10.1007/s12105-020-01258-5]
7. Schafer DR, Thompson LD, Smith BC, Wenig BM. Primary ameloblastoma of the sinonasal tract: a clinicopathologic study of 24 cases. Cancer 1998 Feb 15;82(4):667-74.
https://doi.org/10.1002/(SICI)1097-0142(19980215)82:4<667::AID-CNCR8>3.0.CO;2-I [DOI:10.1002/(SICI)1097-0142(19980215)82:43.0.CO;2-I]
8. Garcia NG, Oliveira DT, Rodrigues MT. Unicystic Ameloblastoma with Mural Proliferation Managed by Conservative Treatment. Case Rep Pathol 2016;2016:3089540. [DOI:10.1155/2016/3089540]
9. Zheng CY, Cao R, Hong WS, Sheng MC, Hu YJ. Marsupialisation for the treatment of unicystic ameloblastoma of the mandible: a long-term follow up of 116 cases. Br J Oral Maxillofac Surg 2019 Sep;57(7):655-62. [DOI:10.1016/j.bjoms.2019.06.002]
10. Sah P, Menon A, Kamath A, Chandrashekar C, Carnelio S, Radhakrishnan R. Role of immunomarkers in the clinicopathological analysis of unicystic ameloblastoma. Dis Markers 2013;35(5):481-8. [DOI:10.1155/2013/517834]
11. Mahadesh J, Rayapati DK, Maligi PM, Ramachandra P. Unicystic ameloblastoma with diverse mural proliferation - a hybrid lesion. Imaging Sci Dent 2011 Mar;41(1):29-33. [DOI:10.5624/isd.2011.41.1.29]
12. Seintou A, Martinelli-Kläy CP, Lombardi T. Unicystic ameloblastoma in children: systematic review of clinicopathological features and treatment outcomes. Int J Oral Maxillofac Surg 2014 Apr;43(4):405-12. [DOI:10.1016/j.ijom.2014.01.003]
13. Lee PK, Samman N, Ng IO. Unicystic ameloblastoma--use of Carnoy's solution after enucleation. Int J Oral Maxillofac Surg 2004 Apr;33(3):263-7. [DOI:10.1006/ijom.2003.0496]
14. Neagu D, Escuder-de la Torre O, Vázquez-Mahía I, et al. Surgical management of ameloblastoma. Review of literature. J Clin Exp Dent 2019 Jan;11(1):e70-e5.
15. Hendra FN, Natsir Kalla DS, Van Cann EM, de Vet HCW, Helder MN, Forouzanfar T. Radical vs conservative treatment of intraosseous ameloblastoma: Systematic review and meta-analysis. Oral Dis 2019 Oct;25(7):1683-96. [DOI:10.1111/odi.13014]
16. Cadavid AMH, Araujo JP, Coutinho-Camillo CM, Bologna S, Junior CAL, Lourenço SV. Ameloblastoma: current aspects of the new WHO classification in an analysis of 136 cases. Surgical and Experimental Pathology 2019 2019/06/14;2(1):17. [DOI:10.1186/s42047-019-0041-z]
17. Ord RA, Blanchaert RH, Jr., Nikitakis NG, Sauk JJ. Ameloblastoma in children. J Oral Maxillofac Surg 2002 Jul;60(7):762-70; discussion, 70-1. [DOI:10.1053/joms.2002.33242]
18. Takahashi K, Miyauchi K, Sato K. Treatment of ameloblastoma in children. Br J Oral Maxillofac Surg 1998 Dec;36(6):453-6. [DOI:10.1016/S0266-4356(98)90462-4]
19. Pogrel MA, Montes DM. Is there a role for enucleation in the management of ameloblastoma? Int J Oral Maxillofac Surg 2009 Aug;38(8):807-12. [DOI:10.1016/j.ijom.2009.02.018]
20. Arotiba GT, Ladeinde AL, Arotiba JT, Ajike SO, Ugboko VI, Ajayi OF. Ameloblastoma in Nigerian children and adolescents: a review of 79 cases. J Oral Maxillofac Surg 2005 Jun;63(6):747-51. [DOI:10.1016/j.joms.2004.04.037]
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