Volume 15, Issue 1 (2026)
WJPS 2026, 15(1): 17-22 |
Back to browse issues page
1- Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran
2- Student Research Committee, Faculty of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran
3- Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran ,alireza.ebrahimpour.1996@gmail.com
2- Student Research Committee, Faculty of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran
3- Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran ,
Abstract: (1168 Views)
Ameloblastic fibro-odontoma (AFO) is a rare benign mixed odontogenic tumor characterized by both soft tissue proliferation and dental hard tissue formation. This case report presents a 16-month-old male with AFO in the anterior mandible, representing one of the youngest documented cases. The patient presented with progressive facial swelling first noted at 10 months of age. Clinical examination revealed facial asymmetry with non-tender buccal expansion, while CT imaging demonstrated a well-defined 23×28mm lytic lesion with internal calcifications in the right parasymphyseal region. Treatment consisted of conservative surgical enucleation and curettage under general anesthesia, with extraction of involved teeth. Histopathological analysis confirmed the diagnosis of AFO, showing islands of ameloblastic epithelium within mesenchymal stroma and evidence of dentin and cementum formation. A literature review of AFO cases in children under 5 years (2014-2024) yielded eight cases with equal gender distribution and no clear predilection for maxilla versus mandible. All reported cases showed lesional expansion, and most were treated with enucleation and curettage with no recurrence noted during follow-up periods. The patient recovered uneventfully with resolution of facial asymmetry and showed no signs of recurrence at six-month follow-up. This case highlights that AFO could manifest at an exceptionally young age, expanding the recognized age range and underscoring the effectiveness of conservative surgical management for this rare odontogenic tumor.
References
1. Liu S, Li H, Dong Y, Zhang D. Ameloblastic fibrosarcoma of the maxilla arising in an old woman, a rare case report and literature review. BMC Oral Health 2024 2024/06/27;24(1):743. [DOI:10.1186/s12903-024-04509-x]
2. Omar N, Ullah A, Ghleilib I, Patel N, Abdelsayed RA. A Locally Aggressive Ameloblastic Fibro-Odontoma: A Case Report and Literature Review. Cureus 2021 Dec;13(12):e20366. [DOI:10.7759/cureus.20366]
3. Ferreira GZ, Danieletto-Zanna CF, Iwaki Filho L, Lustosa RM, Jacomacci WP, Gonçales ES. Ameloblastic fibro-odontoma in a child patient: case report and literature review: case report and literature review. Research, Society and Development 2021;10(2):1-2. [DOI:10.33448/rsd-v10i2.12430]
4. Aldelaimi TN, Khalil AA, Abdulkaream SM. Ameloblastic Fibro-Odontoma of the Mandible. Arab Board Med J 2024;25(3):170-3. [DOI:10.4103/abmj.abmj_4_24]
5. Kurimoto T, Yamanishi T, Harada T, et al. Differential diagnosis of ameloblastic fibro-odontoma: case report and literature review. Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology 2019 2019/01/01/;31(1):38-42. [DOI:10.1016/j.ajoms.2018.07.001]
6. Mahdavi N, Kardooni Khoozestani N, Hasheminasab M, Soltani N. Hybrid Odontogenic Tumor of Calcifying Odontogenic Cyst and Ameloblastic Fibroma: a Case Report and Review of Literature. J Dent (Shiraz) 2020 Jun;21(2):153-7.
7. Sánchez-Romero C, Paes de Almeida O, Bologna-Molina R. Mixed odontogenic tumors: A review of the clinicopathological and molecular features and changes in the WHO classification. World J Clin Oncol 2021 Dec 24;12(12):1227-43. [DOI:10.5306/wjco.v12.i12.1227]
8. Goel M, Qamar A, Daftary M, Chhabile S, Pundkar S. Ameloblastic Fibro-Odontoma of the Posterior Mandible: A Rare Pathological Entity. Cureus 2023 Sep;15(9):e46264. [DOI:10.7759/cureus.46264]
9. Mashhadiabba F, Shamloo N, Jafari M, Vafadar S. Ameloblastic Fibro-Odontoma in a 7-Month-Old Infant: A Case Report. J Dent (Shiraz) 2017 Sep;18(3):234-6.
10. Lin YC, Hsu HM, Liu CS, Yuan K. A peripheral ameloblastic fibro-odontoma in a 3-year-old girl: case report, immunohistochemical analysis, and literature review. Case Rep Dent 2014;2014:321671. [DOI:10.1155/2014/321671]
11. Ülgür II, Caduff R, Erb J, van Waes H, Jacobsen C, Bredell MG. Ameloblastic fibro-odontoma located in the maxilla of a 3-year-old girl. Pediatric Dental Journal 2014 2014/08/01/;24(2):106-10. [DOI:10.1016/j.pdj.2013.12.004]
12. Zahra Jahanshahiafshar, Mina Yazdizadeh, Ramin Forooghi, Maryam Johari. An Ameloblastic fibro-odontoma in the posterior maxilla. Journal of Dentomaxillofacil Radiology, Pathology and Surgery 2022; 11(1): 19-23. magiran.com/p2432083
13. Ghandehari-Motlagh M, Khosravi Z, Meighani G, Baradaran-Nakhjavani Y. Ameloblastic Fibro-Odontoma in a 4-Year-Old Boy. Iran J Pediatr 2016;26(2):e3124. doi:10.5812/ijp.3124 [DOI:10.5812/ijp.3124]
14. Ponniah I, Gopalakrishnan S, Selvam SP, Sharief RM. Ameloblastic fibro-odontoma with ameloblastin immunohistochemistry. Austin J Dent 2020;7(4):1148.
15. Mirmohamad Sadeghi H, Fayazi Boroujeni M, Poorian B. A report of ameloblastic fibro-odontoma in the 29-month-old girl: a case report. J Craniomax Res 2018;5(3):131-135.
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |