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:: Volume 6, Issue 1 (1-2017) ::
wjps 2017, 6(1): 54-61 Back to browse issues page
Effect of Systemic Antioxidant Allopurinol Therapy on Skin Flap Survival
Mehdi Rasti Ardakani , Ahmed Al-Dam , Ashkan Rashad , ALi Shayesteh Moghadam
Department of Plastic Surgery, Medical Education Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
Abstract:   (1435 Views)


It has been reported that systemic administration of allopurinol improves cell survival. This study was aimed to evaluate effects of allopurinol on skin flaps in dogs.


Twenty dogs underwent one skin flap surgery with a 2-week interval. The first procedure was performed according to the standard protocols. The second phase was started by a 1-week pretreatment with allopurinol. Length of the necrotic zone was measured and recorded daily. At each phase, flaps were removed and sent for histopathological study after 1 week observation.


Mean length of the necrotic zone in allopurinol treated skin flaps has been significantly less than normal flaps over all 7 days of observation (p<0.0001). Histopathology study showed less inflammation and more normal tissue structure in the allopurinol treated skin flaps.


It was demonstrated that systemic administration of allopurinol significantly improved skin flap survival.

Keywords: Allopurinol, Antioxidant, Skin flap, Survival
Full-Text [PDF 1475 kb]   (757 Downloads)    
Type of Study: Original Article | Subject: General
Received: 2016/02/26 | Accepted: 2016/12/22 | Published: 2016/12/22
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Rasti Ardakani M, Al-Dam A, Rashad A, Shayesteh Moghadam A. Effect of Systemic Antioxidant Allopurinol Therapy on Skin Flap Survival. wjps. 2017; 6 (1) :54-61
URL: http://wjps.ir/article-1-233-en.html

Volume 6, Issue 1 (1-2017) Back to browse issues page
مجله جهانی جراحی پلاستیک World Journal of Plastic Surgery
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