:: Volume 7, Issue 1 (1-2018) ::
wjps 2018, 7(1): 45-50 Back to browse issues page
The Wound Healing Effects of Herbal Cream Containing Oliveria Decumbens and Pelargonium Graveolens Essential Oils in Diabetic Foot Ulcer Model
Mohaddese Mahboubi , Mohsen Taghizadeh , Tahereh Khamechian , Omid Reza Tamtaji , Rasoul Mokhtari , Sayyed Alireza Talaei
Microbiology Department, Medicinal Plant Research Center of Barij, Kashan, Iran
Abstract:   (1016 Views)

The number of diabetic patients in adult population is increasing. All this population are at risk of developing diabetic foot ulcers (DFUs) that are associated with unwanted ailments and high mortality. In spite of current therapies for DFUs, further therapies are needed to help the patients.
The efficacy of herbal cream containing Pelargonium graveolens and Oliveria decombens essential oils was evaluated topically for treatment of DFUs in rat animal model in comparison with two other herbal formulas containing each essential oil alone, placebo (the basic formula without active ingredients) and normal saline as control groups. After anesthesia of diabetic rats (n=75) induced by streptozotocin (STZ), diabetic wounds were visible on the hind dorsal surface of the foot. The treatments were initiated on Day 1 and repeated 3 times a day for thirteen consecutive days. On day 1, 3, 5, 8 and 13, the wound sizes were determined and assessed histologically.
Three herbal formulations reduced the size of wounds in rats with DFUs, while the cream containing combined herbals of O. decumbens and P. graveolens essential oils had the highest tissue repair in DFU rat models.
Due to better wound healing effects of combined herbal cream containing O. decumbens and P. graveolens essential oils, it can be recommended in treatment of DFUs.

Keywords: Herbal, Oliveria decumbens, Pelargonium graveolens, Diabetic foot ulcer
Full-Text [PDF 359 kb]   (488 Downloads)    
Type of Study: Original Article | Subject: General
Received: 2016/12/5 | Accepted: 2018/01/27 | Published: 2018/01/27

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Volume 7, Issue 1 (1-2018) Back to browse issues page