WORLD JOURNAL OF PLASTIC SURGERY
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Volume 1, Issue 2 (2012)
WJPS 2012, 1(2): 64-70 |
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Fatemi M J, Forootan K S, Jalali S Z S, Mousavi S J, Pedram M S. The Effect of Enoxaparin and Clopidogrel on Survival of Random Skin Flap in Rat Animal Model. WJPS 2012; 1 (2) :64-70
URL: http://wjps.ir/article-1-35-en.html
URL: http://wjps.ir/article-1-35-en.html
Mohammad Javad Fatemi 
1, Kamal S Forootan2 , Seyed Ziaaddin S Jalali3 , Seyed Jaber Mousavi4 , Mir Sepehr Pedram5
1, Kamal S Forootan2 , Seyed Ziaaddin S Jalali3 , Seyed Jaber Mousavi4 , Mir Sepehr Pedram5
1- Associate Professor of Department of Plastic Surgery, Burn Research Center, Hazrate Fatemeh Hospital, Tehran University of Medical Sciences, Tehran, Iran. , mj-fatemi@sina.tums.ac.ir
2- Associate Professor of Department of Plastic Surgery, Burn Research Center, Hazrate Fatemeh Hospital, Tehran University of Medical Sciences, Tehran, Iran
3- Plastic Surgeon, Vali Asr Police Hospital, Tehran, Iran.
4- Department of Community Medicine, Burn Research Center, Tehran University of Medical Sciences, Tehran, Iran.
5- Veterinary Surgeon, School of Veterinary Medicine, Tehran University, Tehran, Iran.
2- Associate Professor of Department of Plastic Surgery, Burn Research Center, Hazrate Fatemeh Hospital, Tehran University of Medical Sciences, Tehran, Iran
3- Plastic Surgeon, Vali Asr Police Hospital, Tehran, Iran.
4- Department of Community Medicine, Burn Research Center, Tehran University of Medical Sciences, Tehran, Iran.
5- Veterinary Surgeon, School of Veterinary Medicine, Tehran University, Tehran, Iran.
Abstract: (15980 Views)
BACKGROUND
Necrosis of skin flaps is considered as an important complication in reconstructive surgery. We conducted an experimental study to investigate the efficacy of low-molecular weight heparin, clopidogrel and their combination to improve the flap survival.
METHODS
Forty male, adult Sprague-Dawlay rats were divided randomly into 4 groups. Standard rectangular, distally based dorsal random pattern skin flap was elevated. To prevent the graft effect, a sterile sheet was put under the flap. No pharmacological agent was administered for the control group. In group 2, single subcutaneous dose of enoxaparin (3.2 mg/kg) was immediately administrated after surgery. In group 3, clopidogrel (25 mg/kg) was given orally for 7 days. In group 4, both enoxaparin and clopidogrel were administrated. The rats were evaluated on post-operative day 7 for viable and necrotic portions of flaps.
RESULTS
The mean and SD of necrosis was 17.79+2.5 cm in the control group, 16.20±3.1 cm in low-molecular weight heparin, 15.25+3.8 cm in combined therapy group and 13.69+2.7 cm in clopidogrel group. Clopidogrel was the only pharmaceutical agent that produced a significant increase in the flap survival area.
CONCLUSION
Clopidogrel may be an effective pharmaceutical agent that significantly increases viability of random skin flaps in rats, but low-molecular weight heparin and their combination did not have any significant beneficial effects.
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