مجله جهانی جراحی پلاستیک
مجله جهانی جراحی پلاستیک
جمعه 31 فروردین 1403
[Archive]
دوره 10، شماره 2 - ( 1399 )
جلد 10 شماره 2 صفحات 66-61 |
برگشت به فهرست نسخه ها
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Davudov M M, Musayev J, Hasanov A, Fathi H R. The Effect of Diltiazem on Microcirculation of Trans-planted Tissue Flaps: Experimental Study on Rabbits. WJPS 2021; 10 (2) :61-66
URL: http://wjps.ir/article-1-777-fa.html
URL: http://wjps.ir/article-1-777-fa.html
The Effect of Diltiazem on Microcirculation of Trans-planted Tissue Flaps: Experimental Study on Rabbits. مجله جهانی جراحی پلاستیک. 1399; 10 (2) :61-66
چکیده: (2177 مشاهده)
BACKGROUND
The aim of the presented study was to investigate the inhibitory effect of diltiazem on the microcirculation of the tissue flaps created in the delay phe-nomenon applied rabbits.
METHODS
The experiment was performed in Central Research Laboratory of Azerbai-jan Medical University, Baku, Azerbaijan in 2018. Ischemia model on the flaps were formed in 30 rabbits for experiment. The subjects were divided into three groups: I (control) group - consists of 10 rabbits who underwent ischemia model, but no medication had been used during the duration of the experiment; II (comparative) group - consists of 10 rabbits who underwent ischemia model, and during 14 d, with a daily dose of 60 mсg nitroglycerin had been applied; III (main) group - consists of 10 rabbits who underwent ischemia model, and during 14 d, with a daily dose of 45 mg diltiazem had been applied.
RESULTS
There was statistically significant difference between the control and the main groups when comparing the mean values of endothelial hyperplasia (P=0.001). However, we found a statistically significant difference when compared the mean values of the arterial vessel wall thickening in the main and the control groups (P=0.022); and the mean values of thrombosis in the main and the comparative groups (P=0.001).
CONCLUSION
With prescription of diltiazem, endothelial hyperplasia on microcirculatory system, the thickening of arterial vessel walls, the thrombosis in vessel’s passage was rarely seen by statistical difference. The main achievement of our study was to discover the correlation between diltiazem and endothelial hyperplasia.
The aim of the presented study was to investigate the inhibitory effect of diltiazem on the microcirculation of the tissue flaps created in the delay phe-nomenon applied rabbits.
METHODS
The experiment was performed in Central Research Laboratory of Azerbai-jan Medical University, Baku, Azerbaijan in 2018. Ischemia model on the flaps were formed in 30 rabbits for experiment. The subjects were divided into three groups: I (control) group - consists of 10 rabbits who underwent ischemia model, but no medication had been used during the duration of the experiment; II (comparative) group - consists of 10 rabbits who underwent ischemia model, and during 14 d, with a daily dose of 60 mсg nitroglycerin had been applied; III (main) group - consists of 10 rabbits who underwent ischemia model, and during 14 d, with a daily dose of 45 mg diltiazem had been applied.
RESULTS
There was statistically significant difference between the control and the main groups when comparing the mean values of endothelial hyperplasia (P=0.001). However, we found a statistically significant difference when compared the mean values of the arterial vessel wall thickening in the main and the control groups (P=0.022); and the mean values of thrombosis in the main and the comparative groups (P=0.001).
CONCLUSION
With prescription of diltiazem, endothelial hyperplasia on microcirculatory system, the thickening of arterial vessel walls, the thrombosis in vessel’s passage was rarely seen by statistical difference. The main achievement of our study was to discover the correlation between diltiazem and endothelial hyperplasia.
فهرست منابع
1. Langdon J, Patel M, Brennan P, Ord R, editors. Operative oral and maxillofacial surgery. 2nd ed. London: Hodder & Stoughton Ltd; 2010. [DOI:10.1201/b13386]
2. Schrag C, Chang YM, Tsai CY, Wei FC. Complete rehabilitation of the mandible following segmental resection. J Surg Oncol 2006;94:538-545. [DOI:10.1002/jso.20491]
3. Jahollari A, Emrahov A, Tavlaşoğlu M. Effect of bosentan on intimal hyperplasia of carotid artery anastomoses in rabbits. Arch Turk Soc Cardiol 2014;42:147-153. [DOI:10.5543/tkda.2014.13463]
4. Stell P, Maran A. Textbook of head and neck surgery and oncology. 5th ed. India: CRC Press; 2012.
5. Yokoo S, Komori T, Furudoi S. Three dimensional reconstruction after oral oncologic surgery using singe free radial forearm flaps or free rectus abdominis musculocutaneous flaps. J Oral Sci 2004;46:65-70. [DOI:10.2334/josnusd.46.65]
6. Carlson ER. Pectoralis major myocutaneous flap. Oral Maxillofac Surg Clin North Am 2003;15:565-575. [DOI:10.1016/S1042-3699(03)00060-8]
7. Kademani D, Mardini S, Moran SL. Reconstruction of head and neck defects: a systematic approach to treatment. Semin Plast Surg 2008;22:141-155. [DOI:10.1055/s-2008-1081398]
8. Narasimhan HV, Dheeraj D, Darshana D, Sreekumar AV. Contemporary concepts in treatment planning, reconstruction and rehabilitation of the maxillofacial region: an overview of methods used in practice. J Contemp Dent Pract 2012;13:938-944. [DOI:10.5005/jp-journals-10024-1258]
9. Li M, Li J, Meng G, Liu X. Protective effects of diltiazem against vascular endothelial cell injury induced by angiotensin‐II and hypoxia. Clin Exp Pharmacol Physiol 2015;42:337-343. [DOI:10.1111/1440-1681.12371]
10. Tanaka M, Fujiwara H, Shibata Y, Kida M, Suzuka H, Kimura K, et al. Effects of chronic oral administration of nifedipine and diltiazem on occlusive thrombus of small coronary arteries in (NZW x BXSB) F1 male mice. Cardiovasc Res 1992;26:586-592. [DOI:10.1093/cvr/26.6.586]
11. Shea MJ, Bush LR, Romson JL, Driscoll EM, Lucchesi BR. The effect of diltiazem on coronary thrombosis in the conscious canine. Eur J Pharmacol 1982;77:67-70. [DOI:10.1016/0014-2999(82)90538-6]
12. Schumacher WA. Lucchesi BR. Effect of Diltiazem on experimental coronary artery thrombosis in dogs. Pharmacology 1990;41:16-23. [DOI:10.1159/000138695]
13. Bai Y, Hu L, Wu J, Gu Y, Li L, Gao B, et al. Effects of intravenous diltiazem in a rat model of experimental coronary thrombotic microembolism. Exp Ther Med 2013;6:873-882. [DOI:10.3892/etm.2013.1263]
14. Kirchengast M, Münter K. Endothelin and restenosis. Cardiovasc Res 1998;39:550-555. [DOI:10.1016/S0008-6363(98)00143-6]
15. Bevan RD, Bevan JA, Frazee JG. Diltiazem protects against functional changes in chronic cerebrovasospasm in monkeys. Stroke 1988;19:73-79. [DOI:10.1161/01.STR.19.1.73]
| بازنشر اطلاعات | |
 |
این مقاله تحت شرایط Creative Commons Attribution-NonCommercial 4.0 International License قابل بازنشر است. |
