دوره 10، شماره 2 - ( 1399 )                   جلد 10 شماره 2 صفحات 45-40 | برگشت به فهرست نسخه ها


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Ojo A B, Oluwatosin O M, Ademola S A, Akinosun O M. Plasma Zinc Levels in Patients with Chronic Leg Ulcers at University College Hospital, Ibadan, Nigeria. WJPS 2021; 10 (2) :40-45
URL: http://wjps.ir/article-1-782-fa.html
Plasma Zinc Levels in Patients with Chronic Leg Ulcers at University College Hospital, Ibadan, Nigeria. مجله جهانی جراحی پلاستیک. 1399; 10 (2) :40-45

URL: http://wjps.ir/article-1-782-fa.html


چکیده:   (2102 مشاهده)
BACKGROUND
Chronic leg ulcers are defects in the skin below the level of knee persisting for more than six weeks and shows no tendency to heal after three or more months. Zinc is a necessary component of several DNA & RNA polymerases and transferases essential for cell proliferation. Zinc deficiency is known to
retard wound healing by preventing cellular mitosis and disturbance of fibroblast function and collagen synthesis. This study compares zinc levels in patients with chronic leg ulcers with apparently healthy individuals.
METHODS
Five milliliters of venous blood samples was taken from twelve patients with chronic leg ulcers. Five milliliters of venous blood samples was also taken from a control group, who do not have chronic leg ulcers, but are matched with the cases in age (± 5 yr), sex, socioeconomic status and body mass index
(± 3 kg/m2). Plasma zinc levels was determined by atomic absorption spectrophotometry. Principal exposure include the socio-demographic characteristics  of patients, duration of symptoms before presentation, signs of ulcer–site, number, size, depth, base, edge, presence of discharge, enlarged lymph nodesand local neurovascular integrity. The outcome variables include plasma levels of biochemical markers measured –Zinc, serum albumin, total protein.
RESULTS
The plasma zinc levels was significantly lower (P<0.01) in patients with chronic leg ulcer (92.808±16.689 μg/dl) as compared with control subjects (109.413 ± 9.304 μg/dl). There was no statistical differrence in albumin and protein levels in both groups.
CONCLUSION
Patients with chronic leg ulcers have significantly lower plasma zinc levels than apparently healthy individuals.
     
نوع مطالعه: مقالات اصيل | موضوع مقاله: تخصصي
انتشار الکترونیک: 1400/4/4

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