مجله جهانی جراحی پلاستیک
مجله جهانی جراحی پلاستیک
سه شنبه 28 فروردین 1403
[Archive]
دوره 11، شماره 2 - ( 1401 )
جلد 11 شماره 2 صفحات 45-37 |
برگشت به فهرست نسخه ها
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Dadmehr S, Shooshtari Z, Alipour M, Eshghpour M, Shaban B, Vaezi T et al . Is Preemptive Oral Tizanidine Effective on Postoperative Pain Intensity after Bimaxillary Orthognathic Surgery? A Triple-Blind Randomized Clinical Trial. WJPS 2022; 11 (2) :37-45
URL: http://wjps.ir/article-1-926-fa.html
URL: http://wjps.ir/article-1-926-fa.html
Is Preemptive Oral Tizanidine Effective on Postoperative Pain Intensity after Bimaxillary Orthognathic Surgery? A Triple-Blind Randomized Clinical Trial. مجله جهانی جراحی پلاستیک. 1401; 11 (2) :37-45
چکیده: (1888 مشاهده)
Background: We aimed to investigate the effect of preoperative administration of oral tizanidine on postoperative pain intensity after bimaxillary orthognathic surgery.
Methods: All healthy skeletal class III patients who were candidates for bimaxillary orthognathic surgery were enrolled in this triple-blind randomized clinical trial. The study was carried out in the Maxillofacial Surgery Department of Qaem Hospital, Mashhad, Iran; from January 2021 to November 2021. The consecutive patients were randomly divided into tizanidine and placebo groups. One hour prior to anesthesia induction, the tizanidine group received 4 mg Tizanidine dissolved in 10 ml apple juice, whereas the placebo group received an identical glass of plain apple juice. All operations were performed by the same surgical team, under the same general anesthesia protocol. Postoperative pain was measured using the Visual Analogue Scale (VAS) at 3, 6, 12, 18, and 24 hours. For statistical analysis; the significance level was set at 0.05 using SPSS 23.
Results: A total of 60 consecutive patients, consisting of 36 females (60%) and 24 males (40%) with an average age of 25.4 ± 6.0 were recruited. An increasing trend was noticed in the amount of perceived postoperative pain from the 3rd till 12th hour, and then decreased afterward. Nevertheless, the average amount of pain was significantly lower in the tizanidine compared to the placebo group, in all the evaluated time intervals (P<0.001). Moreover, there was a significantly higher requirement for postoperative opioid analgesics in the placebo compared to the tizanidine group (P=0.011).
Conclusion: The addition of oral tizanidine was effective in reducing postoperative pain following bimaxillary orthognathic surgery. Further studies are necessary for more relevancy.
Methods: All healthy skeletal class III patients who were candidates for bimaxillary orthognathic surgery were enrolled in this triple-blind randomized clinical trial. The study was carried out in the Maxillofacial Surgery Department of Qaem Hospital, Mashhad, Iran; from January 2021 to November 2021. The consecutive patients were randomly divided into tizanidine and placebo groups. One hour prior to anesthesia induction, the tizanidine group received 4 mg Tizanidine dissolved in 10 ml apple juice, whereas the placebo group received an identical glass of plain apple juice. All operations were performed by the same surgical team, under the same general anesthesia protocol. Postoperative pain was measured using the Visual Analogue Scale (VAS) at 3, 6, 12, 18, and 24 hours. For statistical analysis; the significance level was set at 0.05 using SPSS 23.
Results: A total of 60 consecutive patients, consisting of 36 females (60%) and 24 males (40%) with an average age of 25.4 ± 6.0 were recruited. An increasing trend was noticed in the amount of perceived postoperative pain from the 3rd till 12th hour, and then decreased afterward. Nevertheless, the average amount of pain was significantly lower in the tizanidine compared to the placebo group, in all the evaluated time intervals (P<0.001). Moreover, there was a significantly higher requirement for postoperative opioid analgesics in the placebo compared to the tizanidine group (P=0.011).
Conclusion: The addition of oral tizanidine was effective in reducing postoperative pain following bimaxillary orthognathic surgery. Further studies are necessary for more relevancy.
فهرست منابع
1. Get persistent links for your reference list or bibliography.
Copy and paste the list, we’ll match with our metadata and return the links.
Members may also deposit reference lists here too.
1. Ansari AH, Shooshtari Z, Alipour M, Abrishami MH, Shirzadeh A, Samieirad S. What Is the Effect of Pre-Emptive Oral Montelukast on Postoperative Pain Following Bimaxillary Orthognathic Surgery? A Triple-Blind Randomized Clinical Trial. J Oral Maxillofac Surg 2022, 80(2):240-247. [DOI:10.1016/j.joms.2021.08.151] [PMID]
4. Samieirad S, Sharifian-Attar A, Eshghpour M, et al. Comparison of Ondansetron versus Clonidine efficacy for prevention of postoperative pain, nausea and vomiting after orthognathic surgeries: A triple blind randomized controlled trial. Med Oral Patol Oral Cir Bucal 2018 Nov 1;23(6):e767-e76. [DOI:10.4317/medoral.22493] [PMID] [PMCID]
7. Naran S, Steinbacher DM, Taylor JA. Current Concepts in Orthognathic Surgery. Plast Reconstr Surg 2018 Jun;141(6):925e-36e. [DOI:10.1097/PRS.0000000000004438] [PMID]
10. Eshghpour M, Mianbandi V, Samieirad S. Intra-and postoperative complications of Le Fort I maxillary osteotomy. J Craniofac Surg 2018;29(8):e797-e803. [DOI:10.1097/SCS.0000000000004828] [PMID]
13. Mohammadi F, Marashi M, Tavakoli I, Khakbaz O. Effects of oral clonidine premedication on hemodynamic status in bimaxillary orthognathic surgery: A double-blind randomized clinical trial. J Craniomaxillofac Surg 2016 Apr;44(4):436-9. [DOI:10.1016/j.jcms.2016.01.004] [PMID]
16. Khechoyan DY. Orthognathic surgery: general considerations. Semin Plast Surg 2013 Aug;27(3):133-6. [DOI:10.1055/s-0033-1357109] [PMID] [PMCID]
19. Mobini A, Mehra P, Chigurupati R. Postoperative Pain and Opioid Analgesic Requirements After Orthognathic Surgery. J Oral Maxillofac Surg 2018 Nov;76(11):2285-95. [DOI:10.1016/j.joms.2018.05.014] [PMID]
22. Panula K, Finne K, Oikarinen K. Incidence of complications and problems related to orthognathic surgery: a review of 655 patients. J Oral Maxillofac Surg 2001;59(10):1128-36. [DOI:10.1053/joms.2001.26704] [PMID]
25. Agbaje J, Luyten J, Politis C. Pain Complaints in Patients Undergoing Orthognathic Surgery. Pain Res Manag 2018;2018:4235025. [DOI:10.1155/2018/4235025] [PMID] [PMCID]
28. Fletcher MC, Spera JF. Management of acute postoperative pain after oral surgery. Dent Clin North Am 2012 Jan;56(1):95-111, viii. [DOI:10.1016/j.cden.2011.09.001] [PMID]
31. Shaikh SI, Nagarekha D, Hegade G, Marutheesh M. Postoperative nausea and vomiting: A simple yet complex problem. Anesth Essays Res 2016 Sep-Dec;10(3):388-96. [DOI:10.4103/0259-1162.179310] [PMID] [PMCID]
34. Yazicioglu D, Caparlar C, Akkaya T, Mercan U, Kulaçoglu H. Tizanidine for the management of acute postoperative pain after inguinal hernia repair: A placebo-controlled double-blind trial. Eur J Anaesthesiol 2016;33(3):215-22. [DOI:10.1097/EJA.0000000000000371] [PMID]
37. Talakoub R, Abbasi S, Maghami E, Zavareh SMHT. The effect of oral tizanidine on postoperative pain relief after elective laparoscopic cholecystectomy. Adv Biomed Res 2016;5: 19. [DOI:10.4103/2277-9175.175905] [PMID] [PMCID]
40. Tabari M, Alipour M, Esalati H. Evaluation of oral tiazinidine effects on [intraoperative] hemodynamic responses during direct laryngoscopy under general anesthesia. Iran Red Cresc Med J 2013;15(7):541. [DOI:10.5812/ircmj.11540] [PMID] [PMCID]
43. Imanaga K, Wajima Zi, Inoue T, Ogawa R. Effect of oral tizanidine on local-anesthetic infiltration pain during epidural catheterization. J Nippon Med School 2004;71(2):105-10. [DOI:10.1272/jnms.71.105] [PMID]
46. Wajima Zi, Yoshikawa T, Ogura A, et al. Oral tizanidine, an α2-adrenoceptor agonist, reduces the minimum alveolar concentration of sevoflurane in human adults. Anesth Analg 2002;95(2):393-6.
https://doi.org/10.1213/00000539-200208000-00028 [DOI:10.1097/00000539-200208000-00028]
49. Hord AH, Denson DD, Azevedo MI. Systemic Tizanidine Hydrochloride (Zanaflex™) Partially Decreases Experimental Postoperative Pain in Rats. Anesth Analg 2001;93(5):1307-9.
https://doi.org/10.1097/00000539-200111000-00056 [DOI:10.1097/00000539-200111000-00057] [PMID]
53. Manfredini D, Romagnoli M, Bosco M. Efficacyof tizanidine hydrochloride in the treatment of myofascial face pain. Minerva Med 2004Apr 2004;95(2):165-71.
54. Ahiskalioglu A, Yayik AM, Ahiskalioglu EO, et al. Ultrasound-guided bilateral superficial cervical block and preemptive single-dose oral tizanidine for post-thyroidectomy pain: a randomized-controlled double-blind study. J Anesth 2018;32(2):219-26. [DOI:10.1007/s00540-018-2468-x] [PMID]
57. Kirmeier R, Truschnegg A, Payer M, Acham S, Schulz K, Jakse N. Evaluation of a muscle relaxant on sequelae of third molar surgery: a pilot study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007;104(3):e8-e14. [DOI:10.1016/j.tripleo.2007.02.024] [PMID]
60. Malanga GA, Gwynn MW, Smith R, Miller D. Tizanidine is effective in the treatment of myofascial pain syndrome. Pain Physician 2002;5(4):422-32. [DOI:10.36076/ppj.2002/5/422]
62. Pal US, Kumar L, Mehta G, et al. Trends in management of myofacial pain. Natl J Maxillofac Surg 2014;5(2):109. [DOI:10.4103/0975-5950.154810] [PMID] [PMCID]
65. Kim S-G, Park S-S. Incidence of complications and problems related to orthognathic surgery. J Oral Maxillofac Surg 2007;65(12):2438-44. [DOI:10.1016/j.joms.2007.05.030] [PMID]
68. Alizadeh R, Mireskandari S-M, Azarshahin M, et al. Oral clonidine premedication reduces nausea and vomiting in children after appendectomy. Iran J Pediatr 2012;22(3):399.
69. Wadood F, Muhammad R, Jamil M, un Nisa W. Efficacy of ondansetron alone and ondansetron plus dexamethasone in preventing nausea and vomiting after middle ear surgery. Ayub Med Coll Abbottabad 2014;26(1):80-3.
70. Shilpa SN, Shailaja S, Hilda SS. Comparison of Efficacy of Clonidine versus Ondansetron for Prevention of Nausea and Vomiting Post Thyroidectomy: A Double Blind Randomized Controlled Trial. J Clin Diagn Res 2015 May;9(5):Uc01-3.
71. Tabrizi R, Eftekharian H, Pourdanesh F, Khaghaninejad MS. Does oral clonidine premedication decrease bleeding during open rhinoplasty? J Craniofac Surg 2014 May;25(3):1101-3. [DOI:10.1097/SCS.0000000000000660] [PMID]
| بازنشر اطلاعات | |
 |
این مقاله تحت شرایط Creative Commons Attribution-NonCommercial 4.0 International License قابل بازنشر است. |
