en تخصصي Special مقالات اصيل Original Article <span style="font-size:12pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times=""><b><span style="color:black">Background:</span></b><i> </i>Burn injury is still the leading cause of mortality and morbidity in burn patients<span style="color:black">.&nbsp; We comapred healing effect of <i>Hypericum perforatum</i>, silver sulfadiazine and alpha ointments on burn injuries in rat model. </span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times=""><b><span style="color:black">Methods:</span></b><i> </i><span style="color:black">Sixty female Sprague-Dawley rats in an animal experimental study were randomly divided to 5 equal groups as <i>H. perforatum</i>, silver sulfadiazine and (SSD), alpha, </span><span lang="EN-SG" style="color:black">gel base and the burn injury left untreated.</span><span style="color:black"> Wounds were assessed macroscopically and histologic after burn injury and on days 7^th, 14^th and 21^st after treatments. </span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times=""><b><span style="color:black">Results:</span></b><i> </i><span style="color:black">Burn wounds decreased in size on day 7^th in <i>H. perforatum </i>group (<i>P</i><0.01). Regarding scoring the inflammation, re-epithelialization, angiogenesis, formation of granulation tissue and number of macrophage, the best scores were visible in <i>H. perforatum </i>group, and the worst in the </span><span lang="EN-SG" style="color:black">gel base and the burn injury left untreated </span><span style="color:black">(<i>P</i><0.01).</span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:200%"><span style="tab-stops:254.8pt"><span new="" roman="" style="font-family:" times=""><b><span style="color:black">Conclusions:</span></b><i> </i><i>H. perforatum </i>was shown to significantly induce re-epithelialization, angiogenesis and granulation tissue and decrease the inflammation resulting into a healing process in burn wounds. As <i><span style="color:black">H. perforatum </span></i><span style="color:black">is inexpensive and an easily available herbal medicine, it can be considered as a therapeutic of choice to ameliorate burn injuries.</span></span></span></span></span><br> &nbsp; Burn, Hypericum perforatum, Silver sulfadiazine, Alpha ointment, Wound healing 57 65 http://wjps.ir/browse.php?a_code=A-10-299-9&slc_lang=en&sid=1 Zahra Sadat Hamedi 100319475328460016192 100319475328460016192 No Division of Hematology, Oncology and Palliative Care, Department of Internal Medicine, Virginia Commonwealth University Health System, Richmond, Virginia Amir Manafi 100319475328460016193 100319475328460016193 No Department of Anesthesiology, Arrowhead Regional Medical Center, Colton, California Seyedeh-Sara Hashemi sara_hashemi@sums.ac.ir 100319475328460016194 100319475328460016194 Yes Burn and Wound Healing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Davood Mehrabani 100319475328460016195 100319475328460016195 No Stem Cell Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Anahita Seddighi 100319475328460016196 100319475328460016196 No Department of Molecular Biology, Universität Wien, Wien, Austria Nader Tanideh 100319475328460016197 100319475328460016197 No Stem Cell Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Maral Mokhtari 100319475328460016198 100319475328460016198 No Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran