WORLD JOURNAL OF PLASTIC SURGERY

en Effectiveness of Cryolipolysis in Body Contouring and Fat Reduction: A Systematic Review and Meta-analysis تخصصي Special مروری Review Article Background: Cryolipolysis has emerged as a promising, non-invasive body contouring technique that employs controlled cooling to selectively eliminate adipocytes without damaging surrounding skin or tissues. As global demand rises for non-surgical aesthetic treatments, cryolipolysis offers an appealing alternative to traditional liposuction for individuals seeking fat reduction with minimal recovery time and fewer complications. Methods: Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a comprehensive search of PubMed, Scopus, and Web of Science was conducted up to November 2024. Studies included were randomized controlled trials and prospective cohort studies evaluating the outcomes of cryolipolysis on body contouring. Statistical analysis was performed using Review Manager 5.4 software, calculating mean differences (MD) and 95% confidence intervals (CI). Results: The use of cryolipolysis was associated with decreased BMI showing MD= -1.71 (95%CI: -2.6, -0.82, P=0.0002). However, no significant difference was observed regarding weight with MD= -1.81 (95%CI: -3.93, 0.31, P=0.09). The use of cryolipolysis was also associated with decreased circumference of different body parts with MD= -3.45 (95%CI: -5.55, -1.34, P=0.001), and I2=92%, P<0.00001 and decreased fat thickness with MD= -3.56 (95CI: -4.63, -2.48, P<0.00001), and I2=95%, P<0.00001. Conclusion: Cryolipolysis is effective in reducing BMI, local circumference, and fat thickness, confirming its utility for non-invasive body contouring. However, it does not significantly affect overall weight. The benefits are more pronounced in short-term follow-up and vary by body region. Further long-term and comparative studies are recommended.   Cryolipolysis, Body Contouring, Non-Invasive Fat Reduction, BMI, Circumference, Fat Thickness 16 26 http://wjps.ir/browse.php?a_code=A-10-1082-3&slc_lang=en&sid=1 Alaa Hakami alaahakami@jazanu.edu.sa 100319475328460017499 0009-0009-2007-5409 Yes 1. Department of Surgery, Jazan University Jazan, Saudi Arabia Alya Hakami 100319475328460017500 100319475328460017500 No 1. Department of Surgery, Jazan University Jazan, Saudi Arabia Rayan Alghamdi 100319475328460017501 100319475328460017501 No 2. Department of Surgery, Al-Imam Mohammad Ibn Saud Islamic University, Riyadh, Saudi Arabia Haya Alzahrani 100319475328460017502 100319475328460017502 No 3. Department of Surgery, Al-Baha University, Saudi Arabia Adham Alghamdi 100319475328460017503 100319475328460017503 No 3. Department of Surgery, Al-Baha University, Saudi Arabia Abdullah Qureshey 100319475328460017504 100319475328460017504 No 4. Department of Surgery, University of Jeddah, Jeddah, Saudi Arabia Yousef Almail 100319475328460017505 100319475328460017505 No 5. Department of Surgery, Royal College of Surgeons in Ireland, Dublin, Ireland Manar Alfaqiri 100319475328460017506 100319475328460017506 No 6. Department of Surgery, University of Tabuk, Tabuk, Saudi Arabia Maha Alsofiani 100319475328460017507 100319475328460017507 No 7. Department of Surgery, Taif university, Taif, Saudi Arabia Lana Hariri 100319475328460017508 100319475328460017508 No 8. Department of Surgery, King Abdulaziz University, Jeddah, Saudi Arabia Hajar Alrashed 100319475328460017509 100319475328460017509 No 9. Department of Surgery, Princesses Nourah University, Riyadh, Saudi Arabia Shahad Aldumkh 100319475328460017510 100319475328460017510 No 10. Department of Surgery, King Saud University, Riyadh, Saudi Arabia