en عمومى General مقالات اصيل Original Article <p></p> <p></p> <p><strong>BACKGROUND</strong></p> <p><em>Staphylococcus aureus</em> is one of the most causative organisms in the skin wound infections. Development of resistant<em> S. aureus</em> to current treatments in individuals with low immunity is a global concern. The aim of this study was to evaluate the efficacy of herbal formulation against skin wound infection<strong>. </strong></p> <p><strong>METHODS</strong></p> <p>The efficacy of herbal formulation containing <em>Oliveria decumbens</em> and <em>Pelargonium graveolens</em> essential oils was evaluated in comparison to mupirocin against Methicillin Resistant <em>S. aureus</em> (MRSA) related skin wound infection in mice animal model.</p> <p><strong>RESULTS</strong></p> <p>The herbal cream and mupirocin decreased the log CFU by 2.5&plusmn;0.26 and 2.46&plusmn;0.32, respectively, while the log CFU of <em>S. aureus</em> from wound skin were 5.9&plusmn;0.26 and 5.65&plusmn;0.23 for placebo and control groups, respectively. Moreover, the histological examinations showed that this cream improved the wound healing and increased the collagen deposition and wound contraction.</p> <p><strong>CONCLUSION</strong></p> <p>This natural new formulation with <em>O. decumbens</em> and <em>P. graveolens</em> essential oils could be recommended as a new candidate for wound healing.</p> Oliveria decumbens, Pelargonium graveolens, Healing, Infected wound, Mouse 259 264 http://wjps.ir/browse.php?a_code=A-10-163-1&slc_lang=en&sid=1 Mohaddese Mahboubi mahboubi1357@yahoo.com 10031947532846002495 10031947532846002495 Yes Microbiology Department, Medicinal Plant Research Center of Barij, Kashan, Iran Mohammad Mehdi Feizabadi mfeizabadi@tums.ac.ir 10031947532846002496 10031947532846002496 No Department of Microbiology, School of Medicine, Tehran University of Medical Science, Tehran, Iran Tahereh Khamechian khamechian_t@yahoo.com 10031947532846002497 10031947532846002497 No Department of Pathology, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, Iran Nastaran Kazempour nkazempour@yahoo.com 10031947532846002498 10031947532846002498 No Microbiology Department, Medicinal Plant Research Center of Barij, Kashan, Iran Mohsen Razavi Zadeh mohsen_razavizadeh@yahoo.com 10031947532846002499 10031947532846002499 No Gastroenterology Department, Beheshti Hospital, Kashan University of Medical Sciences, Kashan, Iran Farhang Sasani Fsasani@ut.ac.ir 10031947532846002500 10031947532846002500 No Department of Pathology, Faculty of Veterinary Medicine, Tehran University, Tehran, Iran Mohsen Bekhradi mohsen.bekhradi@yahoo.com 10031947532846002501 10031947532846002501 No Formulation Department, Medicinal Plant Research Center of Barij, Kashan, Iran