en عمومى General مقالات اصيل Original Article <p style="margin:0in;margin-bottom:.0001pt;text-align:justify;line-height:200%"><strong><span style="color:black">BACKGROUND<!--stripped--><!--stripped--></span></strong></p> <p style="margin:0in;margin-bottom:.0001pt;text-align:justify;line-height:200%"><span style="color:black">It has been reported that systemic administration of allopurinol improves cell survival. This study was aimed to evaluate effects of allopurinol on skin flaps in dogs.<!--stripped--><!--stripped--></span></p> <p style="margin:0in;margin-bottom:.0001pt;text-align:justify;line-height:200%"><strong><span style="color:black">METHODS<!--stripped--><!--stripped--></span></strong></p> <p style="margin:0in;margin-bottom:.0001pt;text-align:justify;line-height:200%"><span style="color:black">Twenty dogs underwent one skin flap surgery with a 2-week interval. The first procedure was performed according to the standard protocols. The second phase was started by a 1-week pretreatment with allopurinol. Length of the necrotic zone was measured and recorded daily. At each phase, flaps were removed and sent for histopathological study after 1 week observation.<!--stripped--><!--stripped--></span></p> <p style="margin:0in;margin-bottom:.0001pt;text-align:justify;line-height:200%"><strong><span style="color:black">RESULTS<!--stripped--><!--stripped--></span></strong></p> <p style="margin:0in;margin-bottom:.0001pt;text-align:justify;line-height:200%"><span style="color:black">Mean length of the necrotic zone in allopurinol treated skin flaps has been significantly less than normal flaps over all 7 days of observation (<i>p</i><0.0001). Histopathology study showed less inflammation and more normal tissue structure in the allopurinol treated skin flaps.<!--stripped--><!--stripped--></span></p> <p style="margin:0in;margin-bottom:.0001pt;text-align:justify;line-height:200%"><strong><span style="color:black">CONCLUSION<!--stripped--><!--stripped--></span></strong></p> <p style="margin:0in;margin-bottom:.0001pt;text-align:justify;line-height:200%"><span style="color:black">It was demonstrated that systemic administration of allopurinol significantly improved skin flap survival.<!--stripped--><!--stripped--></span></p> Allopurinol, Antioxidant, Skin flap, Survival 54 61 http://wjps.ir/browse.php?a_code=A-10-185-1&slc_lang=en&sid=1 Mehdi Rasti Ardakani 10031947532846002964 10031947532846002964 No Department of Plastic Surgery, Isfahan University of Medical Sciences, Isfahan, Iran Ahmed Al-Dam 10031947532846002965 10031947532846002965 No Department of Oral and Maxillofacial Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. Ashkan Rashad 10031947532846002966 10031947532846002966 No Department of Oral and Maxillofacial Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. ALi Shayesteh Moghadam 10031947532846002967 10031947532846002967 Yes Department of Plastic Surgery, Medical Education Research Center, Isfahan University of Medical Sciences, Isfahan, Iran