en عمومى General مقالات اصيل Original Article <p><strong>BACKGROUND</strong></p> <p>Craniosynostosis results from premature closure of one or more cranial sutures, leading to deformed calvaria and craniofacial skeleton at birth. Postoperative complications and outcome in intensive care unit (ICU) is related to surgical method and perioperative management. This study determined the perioperative risk factors, which affect outcome of patients after craniosynostosis surgery.</p> <p><strong>METHODS</strong></p> <p>In a retrospective study, 178 patients with craniosynostosis who underwent primary cranial reconstruction were included. Postoperative complications following neurosurgical procedures including fever in ICU, level of consciousness, re-intubation, and blood, urine, and other cultures were also performed and their association with the main outcomes (length of ICU stay) were analyzed.</p> <p><strong>RESULTS</strong></p> <p>Factors independently associated with a longer pediatric ICU stay were fever (OR=1.59, 95% CI=1.25-4.32; <em>p</em>=0.001), perioperative bleeding (OR=2.25, 95% CI=1.65-3.65; <em>p</em>=0.01), age (having surgery after the first 5 years) (OR=1.59, 95% CI=1.33-3.54, <em>p</em>=0.016) and infection (OR=2.17, 95% CI=1.83-7.46; <em>p</em>=0.002).&nbsp; Mean blood loss during surgery was significantly higher in patients whose duration of ICU was longer than 4 days compare to less than 4 day&nbsp; (<em>p</em>=0.026). Amount of bleeding significantly was correlated to duration of surgery (r=0.70, <em>p</em>=0.001) and patient&#39;s age (r=0.23, <em>p</em>=0.44).</p> <p><strong>CONCLUSION</strong></p> <p>perioperative management particularly blood loss could deteriorate patients outcome and length of stay in ICU and hospital. Infections in ICU could deteriorate outcomes.</p> Craniosynostosis, Pediatric, Intensive care unit, Operation 48 53 http://wjps.ir/browse.php?a_code=A-10-207-1&slc_lang=en&sid=1 Abdoljalil Kalantar Hormozi kalantarj@yahoo.com 10031947532846002955 10031947532846002955 No Department of Craniomaxillofacial Surgery, Mofid Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran Nastaran Mahdavi 10031947532846002956 10031947532846002956 No Department of Pediatric Anaesthesiology, Mofid Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran Mohammad Mehdi Foroozanfar 10031947532846002957 10031947532846002957 No Department of Pediatric Anaesthesiology, Mofid Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran Seyed Sajad Razavi 10031947532846002958 10031947532846002958 No Department of Pediatric Anaesthesiology, Mofid Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran Seyed Amir Mohajerani 10031947532846002959 10031947532846002959 No Department of Pediatric Anaesthesiology, Mofid Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran Ahmad Eghbali 10031947532846002960 10031947532846002960 No Department of Pediatric Anaesthesiology, Mofid Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran Amir Ali Mafi amirali.mafi@gmail.com 10031947532846002961 10031947532846002961 No Shahid Beheshti University of Medical Sciences, Tehran, Iran Haleh Hashemzadeh 10031947532846002962 10031947532846002962 No Department of Craniomaxillofacial Surgery, Mofid Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran Alireza Mahdavi alirezamahdavi78@yahoo.com 10031947532846002963 10031947532846002963 Yes Department of Pediatric Anaesthesiology, Mofid Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran