en تخصصي Special مقالات اصيل Original Article <p></p> <p>BACKGROUND<br> Hemangiomas are the most common benign tumors of infancy. This study evaluated the efficacy of oral propranolol comparing to oral steroids in management of pediatric hemangiomas.<br> METHODS<br> In North India from January 2012 to January 2015, sixty children <6 years old with superficial hemangiomas were divided into 2 groups; oral propranolol vs. oral prednisolone. All participants were assessed for electrocardiogram, heart rate, blood pressure and sugar and initial therapy was started using 1 mg/kg and in absence of adverse effects, 2 mg/kg was administered after 2 weeks. The hemangioma Activity Score (HAS) was used for scoring and patients were followed up for 6 months.<br> RESULTS<br> The propranolol group mostly showed early response to the drug and needed the drug for less time compared to corticosteroid group. In propranolol group, 16.5%, 23% and 59% needed the drug to be continued for 8-12, 4-8 and 4 months. In corticosteroid group, the therapy was continued for 8-12, and 4-8 months in 76.8% and 16.5% and in 6.6% was stopped within 4 months. In propranolol group, the response was 70% compared to 40% in other group. The mean HAS decreased significantly in propranolol group when compared to steroid group. Three patients on prednisolone developed Cushingoid features, while 1 patient in propranolol group had mild flue like symptoms.<br> CONCLUSION<br> Two mg/kg of oral propranolol significantly decreased HAS, when compared to oral prednisolone, with good parent satisfaction, minimal adverse effects and no recurrence/relapse of hemangiomas after a follow up period of 6 months.</p> <p></p><p></p><p></p> Pediatric hemangiomas, Propranolol, Corticosteroids 16 24 http://wjps.ir/browse.php?a_code=A-10-170-3&slc_lang=en&sid=1 Adil Ali Adil Ali adilgoa1985@gmail.com 10031947532846006052 10031947532846006052 Yes JNMCH, AMU,Aligarh Umme Aiman aimanjnmc@gmail.com 10031947532846006053 10031947532846006053 No JNMCH, AMU,Aligarh Mohd Azam Haseen azamjnmc@gmail.com 10031947532846006054 10031947532846006054 No JNMCH, AMU,Aligarh Mohd Altaf Mir draltafmir@gmail.com 10031947532846006055 10031947532846006055 No JNMCH, AMU,Aligarh Imran Ghani 10031947532846006056 10031947532846006056 No JNMCH, AMU,Aligarh Ragya Bharadwaj 10031947532846006057 10031947532846006057 No JNMCH, AMU,Aligarh Mohd. Yaseen 10031947532846006058 10031947532846006058 No JNMCH, AMU,Aligarh