WORLD JOURNAL OF PLASTIC SURGERY
مجله جهانی جراحی پلاستیک
WJPS
Medical Sciences
http://wjps.ir
1
admin
2228-7914
2252-0724
8
10.61186/wjps
14
8888
13
en
jalali
1396
10
1
gregorian
2018
1
1
7
1
online
1
fulltext
en
The Effect of Oral Propranolol versus Oral Corticosteroids in Management of Pediatric Hemangiomas
تخصصي
Special
مقالات اصيل
Original Article
<p></p>
<p>BACKGROUND<br>
Hemangiomas are the most common benign tumors of infancy. This study evaluated the efficacy of oral propranolol comparing to oral steroids in management of pediatric hemangiomas.<br>
METHODS<br>
In North India from January 2012 to January 2015, sixty children <6 years old with superficial hemangiomas were divided into 2 groups; oral propranolol vs. oral prednisolone. All participants were assessed for electrocardiogram, heart rate, blood pressure and sugar and initial therapy was started using 1 mg/kg and in absence of adverse effects, 2 mg/kg was administered after 2 weeks. The hemangioma Activity Score (HAS) was used for scoring and patients were followed up for 6 months.<br>
RESULTS<br>
The propranolol group mostly showed early response to the drug and needed the drug for less time compared to corticosteroid group. In propranolol group, 16.5%, 23% and 59% needed the drug to be continued for 8-12, 4-8 and 4 months. In corticosteroid group, the therapy was continued for 8-12, and 4-8 months in 76.8% and 16.5% and in 6.6% was stopped within 4 months. In propranolol group, the response was 70% compared to 40% in other group. The mean HAS decreased significantly in propranolol group when compared to steroid group. Three patients on prednisolone developed Cushingoid features, while 1 patient in propranolol group had mild flue like symptoms.<br>
CONCLUSION<br>
Two mg/kg of oral propranolol significantly decreased HAS, when compared to oral prednisolone, with good parent satisfaction, minimal adverse effects and no recurrence/relapse of hemangiomas after a follow up period of 6 months.</p>
<p></p><p></p><p></p>
Pediatric hemangiomas, Propranolol, Corticosteroids
16
24
http://wjps.ir/browse.php?a_code=A-10-170-3&slc_lang=en&sid=1
Adil
Ali
Adil
Ali
adilgoa1985@gmail.com
10031947532846006052
10031947532846006052
Yes
JNMCH, AMU,Aligarh
Umme
Aiman
aimanjnmc@gmail.com
10031947532846006053
10031947532846006053
No
JNMCH, AMU,Aligarh
Mohd Azam
Haseen
azamjnmc@gmail.com
10031947532846006054
10031947532846006054
No
JNMCH, AMU,Aligarh
Mohd Altaf
Mir
draltafmir@gmail.com
10031947532846006055
10031947532846006055
No
JNMCH, AMU,Aligarh
Imran
Ghani
10031947532846006056
10031947532846006056
No
JNMCH, AMU,Aligarh
Ragya
Bharadwaj
10031947532846006057
10031947532846006057
No
JNMCH, AMU,Aligarh
Mohd.
Yaseen
10031947532846006058
10031947532846006058
No
JNMCH, AMU,Aligarh