en تخصصي Special مقالات اصيل Original Article <p><strong>BACKGROUND</strong><br> Wound healing is the process of repair following an injury to the skin and other soft tissues. In this study, the effect of n-hexane d-chloromethane extract (1: 1) of root <em>Onosma bulbotrichum</em> DC on the second degree burn in rabbit model was investigated.<br> <strong>METHODS</strong><br> Thirty-six adult rabbits of both sexes were randomly divided into six groups, control (without treatment), negative control (treatment with cold cream), positive control (treatment with silver sulfadiazine), and treatment groups with 5%, 1% and 2% <em>O. bulbotrichum</em> cream and assessed histologically.<br> <strong>RESULTS</strong><br> The best result was shown in 5% <em>O. bulbotrichum</em> group similar to silver sulfadiazine group. The maximum amount of collagen and the tensile strength of tissue were observed in 5% <em>O. bulbotrichum</em> and silver sulfadiazine groups. Histopathological examination showed that burn healing in treatment group with 5% <em>O. bulbotrichum</em> was faster than other groups.<br> <strong>CONCLUSION</strong><br> The 5% <em>O. bulbotrichum</em> cream was shown to have healing, and anti-inflammatory effects when used in treatment of second degree burns.</p> Burn, Healing, Silver sulfadiazine, Onosma bulbotrichum, Rabbit 25 33 http://wjps.ir/browse.php?a_code=A-10-242-1&slc_lang=en&sid=1 Aliasghar Hemmati 10031947532846006059 10031947532846006059 No Department of Pharmacology Toxicology, School of Pharmacy, Physiology Research Center, Jundishapur University of Medical Sciences, Ahvaz, Iran Forough Namjuyan 10031947532846006060 10031947532846006060 No Department of Pharmacognosy, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Sadegh Yousefi 10031947532846006061 10031947532846006061 No Department of Pharmacology, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Gholamreza Houshmand 10031947532846006062 10031947532846006062 Yes Department of Pharmacology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Hossein Khadem Haghighian 10031947532846006063 10031947532846006063 No Department of Nutrition, Faculty of Health, Qazvin University of Medical Sciences, Qazvin, Iran Anahita Rezaei 10031947532846006064 10031947532846006064 No Department of Pathology, Faculty of Veterinary Medicine, Shahid Chamran University, Ahvaz, Iran