en عمومى General مقالات اصيل Original Article <p><strong>BACKGROUND</strong><br> The number of diabetic patients in adult population is increasing. All this population are at risk of developing diabetic foot ulcers (DFUs) that are associated with unwanted ailments and high mortality. In spite of current therapies for DFUs, further therapies are needed to help the patients.<br> <strong>METHODS</strong><br> The efficacy of herbal cream containing <em>Pelargonium graveolens</em> and <em>Oliveria decombens</em> essential oils was evaluated topically for treatment of DFUs in rat animal model in comparison with two other herbal formulas containing each essential oil alone, placebo (the basic formula without active ingredients) and normal saline as control groups. After anesthesia of diabetic rats (n=75) induced by streptozotocin (STZ), diabetic wounds were visible on the hind dorsal surface of the foot. The treatments were initiated on Day 1 and repeated 3 times a day for thirteen consecutive days. On day 1, 3, 5, 8 and 13, the wound sizes were determined and assessed histologically.<br> <strong>RESULTS</strong><br> Three herbal formulations reduced the size of wounds in rats with DFUs, while the cream containing combined herbals of <em>O. decumbens</em> and <em>P. graveolens</em> essential oils had the highest tissue repair in DFU rat models.<br> <strong>CONCLUSION</strong><br> Due to better wound healing effects of combined herbal cream containing <em>O. decumbens</em> and <em>P. graveolens</em> essential oils, it can be recommended in treatment of DFUs.</p> Herbal, Oliveria decumbens, Pelargonium graveolens, Diabetic foot ulcer 45 50 http://wjps.ir/browse.php?a_code=A-10-163-2&slc_lang=en&sid=1 Mohaddese Mahboubi mahboubi1357@yahoo.com 10031947532846006104 10031947532846006104 Yes Microbiology Department, Medicinal Plant Research Center of Barij, Kashan, Iran Mohsen Taghizadeh mohsenta44@yahoo.com 10031947532846006105 10031947532846006105 No Research Center for Biochemistry and Nutrition in Metabolic diseases, Kashan University of Medical Sciences, Kashan, Iran Tahereh Khamechian Khamechian@yahoo.com 10031947532846006106 10031947532846006106 No Department of Pathology, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, Iran. Omid Reza Tamtaji amtaji_or@yahoo.com 10031947532846006107 10031947532846006107 No Research Center for Biochemistry and Nutrition in Metabolic diseases, Kashan University of Medical Sciences, Kashan, Iran Rasoul Mokhtari Mokhtari@yahoo.com 10031947532846006108 10031947532846006108 No Research Center for Biochemistry and Nutrition in Metabolic diseases, Kashan University of Medical Sciences, Kashan, Iran Sayyed Alireza Talaei talaeizavareh@yahoo.com 10031947532846006109 10031947532846006109 No Physiology Research Center, Kashan University of Medical Sciences, Kashan, Iran