fa عمومى General مقالات اصيل Original Article <strong>BACKGROUND</strong><br> Restoration of craniofacial bone defects has been a concern for oral and maxillofacial surgeons. In this study, the healing effect of fibrin glue scaffold was compared with autologous bone graft in mandibular defects of rabbit.<br> <strong>METHODS</strong><br> Bilateral unicortical osteotomy was performed in the diastema region of 10 male Dutch rabbits. The subjects were randomly divided into 2 equal groups. The mandibular defect on the right side was treated with fibrin glue scaffold and the defect on the left side with autologous bone graft provided from iliac crest. After 4 and 8 weeks, five rabbits from each group were sacrificed and the defects were evaluated morphologically, by coronal computed tomography scanning (CT-scan) and by histological examinations.<br> <strong>RESULTS</strong><br> The healing effect of fibrin glue scaffold and autologous bone graft was similar with appropriate osteogenesis in comparison to the control group.<br> <strong>CONCLUSION</strong><br> Using fibrin glue can be a non-invasive treatment of choice in mandibular defects and maxillofacial surgeries when compared with autologous bone graft. Fibrin glue, Scaffold, Autologous bone graft, Mandibular defect, Rabbit 3 11 http://wjps.ir/browse.php?a_code=A-10-1-67&slc_lang=fa&sid=1 Azizollah Khodakaram-Tafti 10031947532846005039 10031947532846005039 No Department of Pathobiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran Davood Mehrabani mehrabanittrc@gmail.com 10031947532846005040 10031947532846005040 Yes Stem Cell Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Hanieh Shaterzadeh-Yazdi 10031947532846005041 10031947532846005041 No Department of Pathobiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran Barbad Zamiri 10031947532846005042 10031947532846005042 No Department of Craniomaxillofacial Surgery, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran Mahsa Omidi 10031947532846005043 10031947532846005043 No Department of Oral and Maxillofacial Radiology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran