en عمومى General مقالات اصيل Original Article BACKGROUND<br> Ischemia of skin flaps is an important complication in reconstructive surgery. This study evaluated the efficacy of topical vitamins A and E on improving flap survival.&nbsp;<br> METHODS<br> Twenty-four white-albino male rats were randomly divided into two groups of treatment and control. Standard rectangular, distally based dorsal random pattern skin flap was elevated. Intra-peritoneal cephazoline was administered to prevent any unexpected infection. No pharmaceutical agent was administered for the control group, but pure vaseline ointment. In treatment group, vaseline plus vitamins A and E were administrated daily after surgery for 10 days. The rats were evaluated on the 10th day after surgery for viable and necrotic portions of the flaps.&nbsp;<br> RESULTS<br> The mean values of necrosis in the flaps were 625&plusmn;189.56 and 920.00&plusmn;247.31 in the treatment and control groups, respectively. Vaseline plus vitamins increased flap survival significantly. CONCLUSION<br> Topical vitamins A and E may be effective pharmaceutical agents to increase viability of random skin flaps in rats. They can be added to vasoactive topical agents to reach better results. Vitamin A, Vitamin E, Ischemia, Skin flap, Survival, Rat 58 61 http://wjps.ir/browse.php?a_code=A-10-200-2&slc_lang=en&sid=1 Seyed Esmail Hassanpour hassanpour1394@sbmu.ac.ir 10031947532846006481 10031947532846006481 No professor of plastic &reconstructive surgery, medicine school, TShahid Beheshti University of Medical Sciences, Tehran, Iran Khalil Rostami k.rostami@yagoo.com 10031947532846006482 10031947532846006482 No assistant professor of plastic &reconstructive surgery, medicine school, TShahid Beheshti University of Medical Sciences, Tehran, Iran Eznollah Azargashb 10031947532846006483 10031947532846006483 No Assistant Professor of Departmen of community medicine,School of medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Kourosh Saberi 10031947532846006484 10031947532846006484 No Assistant Professor of plastic & reconstructive surgery .Semnan University of Medical Sciences, Semnan, Iran Seyyed Hosein Hamraz 10031947532846006485 10031947532846006485 No Aassistant professor of plastic &reconstructive sushahid Beheshti University of Medical Sciences, Tehran, Iran Fatemeh Farajzadeh Vajari fatemeh_582003@yahoo.com 10031947532846006486 10031947532846006486 No Gynecologist surgeon, Privat practice , Tehran, Iran Hojjat Molaei hmggprs@gmail.com 10031947532846006487 10031947532846006487 Yes Aassistant professor of plastic &reconstructive surgery, medicine school, Tehran University of Medical Sciences, Tehran, Iran