en تخصصي Special مقالات اصيل Original Article <strong>BACKGROUND</strong><br> Delay phenomenon can be used for better blood supply of the flap in plastic surgery. Effects of Montelukast have been observed to reduce ischemia/reperfusion injury in various organs due to angiogenic and anti-oxidant effects. The present study aimed to determine the role of Montelukast as medical delay of the flaps.<br> <strong>METHODS</strong><br> In this experimental study, 42 Wistar rats were divided into 3 equal groups. These groups were Surgical Delay Group (SDG), Medical Delay Group (MDG) and Control Group (CG). In SDG, 8&times;3 cm rectangular randomized random skin flap was first surgically delayed at rats&rsquo; back. The MDG received 10 mg/kg oral Montelukast via orogastric tube for 5 days as medical delay. In MDG and SDG flap, harvesting was undertaken after a delayed period, but there was not any delayed period in CG. After delayed period, a segment of the skin flap was biopsied for assessing angiogenesis. After 14^th days, the photos were taken and the size of the necrotic area of the flap was measured.<br> <strong>RESULTS</strong><br> A significant difference was observed between the mean survival and angiogenesis (<em>p</em>=0.002). The same performance was reported between MDG and SDG, which were alike regarding survival and angiogenesis (<em>p</em>>0.05); while there was a significant difference between the control and surgical groups, as well as control and medical groups (<em>p</em><0.05). Finally, the inflammation showed no significant difference (<em>p</em>>0.05).<br> <strong>CONCLUSION</strong><br> Regarding positive effects of Montelukast on survival and angiogenesis, it is recommended to be used as a medication for larger studies. Flaps, Medical delay, Montelukast 48 54 http://wjps.ir/browse.php?a_code=A-10-51-2&slc_lang=en&sid=1 Maryam Iranpour miranpour@kmu.ac.ir 10031947532846007666 10031947532846007666 No Department of Pathology, Pathology and Stem Cell Research Center, Kerman University of Medical Sciences, Kerman, Iran Ali Khodarahmi khodarahmiali@yahoo.com 10031947532846007667 10031947532846007667 Yes Department of Surgery, Pathology and Stem Cell Research Center, Kerman University of Medical Sciences, Kerman, Iran Nima Khodarahmi khodarahminima@yahoo.com 10031947532846007668 10031947532846007668 No Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran Mohammad Shafiee khodarahmiali@yahoo.com 10031947532846007669 10031947532846007669 No Assistant Professor of Surgery HPB and Transplant Surgeon, Afzalipoor Hospital , Kerman Reza Malekpourafshar khodarahmiali@yahoo.com 10031947532846007670 10031947532846007670 No Department of Pathology, Pathology and Stem Cell Research Center, Kerman University of Medical Sciences, Kerman, Iran Nozar Nakhaee khodarahmiali@yahoo.com 10031947532846007671 10031947532846007671 No Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran