en عمومى General مقالات اصيل Original Article <strong>BACKGROUND</strong><br> Several methods have been used to decrease the periorbital edema and ecchymosis after rhinoplasty. In this study, we evaluated the efficacy of hirudoid and dexamethasone in reduction of the periorbital edema and ecchymosis.<br> <strong>METHODS</strong><br> Sixty patients who underwent primary rhinoplasty were randomly divided into 3 groups. Group H received hirudoid cream, 3 times per day for 5 days from postoperative-day (POD). Group D received 10 mg of dexamethasone IV, immediately before surgery; and group C (control) received neither dexamethasone nor hirudoid. Two surgeons who were unaware of administered medications rated the severity of edema and intensity of ecchymosis, on 2^nd, 5^th, and 7^th POD.<br> <strong>RESULTS</strong><br> On 2^nd POD, the edema in group D was significantly lower than groups H and C; but there was no significant difference in severity and intensity of ecchymosis between 3 groups. On 7^th POD, the intensity of ecchymosis was significantly lower in group H in comparison to group C. When the difference between 2^nd and 7^th POD was evaluated, the resolution of severity of edema and intensity of ecchymosis was significantly better in group H (<em>p</em><0.001).<br> <strong>CONCLUSION</strong><br> Hirudoid was shown to be effective in reducing edema and ecchymosis after rhinoplasty. The use of dexamethasone was effective in prevention of periorbital edema at early postoperative days, but it was not effective on resolution of ecchymosis. Hirodoid, Ecchymosis, Edema, Periorbital, Eye, Rhinoplasty 128 134 http://wjps.ir/browse.php?a_code=A-10-318-4&slc_lang=en&sid=1 Khalil Rostami 10031947532846008513 10031947532846008513 No Department of Plastic and Reconstructive Surgery, Shahid Modares Educational Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran Mohammad Ali Shahaboddin 10031947532846008514 10031947532846008514 No Department of Plastic and Reconstructive Surgery, Shahid Modares Educational Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran Feizollah Niazi 10031947532846008515 10031947532846008515 No Department of Plastic and Reconstructive Surgery, Shahid Modares Educational Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran Arian Karimi Rouzbahani 10031947532846008516 10031947532846008516 No Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran Sedigheh Nadri 10031947532846008517 10031947532846008517 No Department of Surgery, Lorestan University of Medical Sciences, Khorramabad, Iran Hormoz Mahmoudvand drmahmoudvand@gmail.com 10031947532846008518 10031947532846008518 Yes Department of Surgery, Lorestan University of Medical Sciences, Khorramabad, Iran