en عمومى General مقالات اصيل Original Article BACKGROUND<br> Methamphetamine (METH) may be administered for weight loss purposes and to understand the METH side-effects more in details, this study aimed at determining the effect of METH on changes in adipose tissue in experimental rats.<br> METHODS<br> Forty five male Wistar rats were randomly allocated to three equal groups. Group 1 was experimental receiving METH [0.4 mg/kg, subcutaneously (S/C), 0.6 mL/rat] for 3 weeks, group 2 was the sham group receiving normal saline (0.6 mL/rat, S/C) and the 3rd group was the control receiving distilled water, identically. The elevated plus maze test was used to confirm cognitive impairment and distraction as anxiety and to verify addiction to METH by assessing the percent time spent in open arm (OAT), the percent time spent in closed arm (CAT), the percent time spent in central parts and head dipping over the side of the maze. Adipose tissue was assessed histologically 7, 14 and 21-days after interventions.&nbsp;<br> RESULTS<br> A significant increase in anxiety level, and histologically inflammation, degeneration and necrosis in adipose tissue were visible after METH use.&nbsp;<br> CONCLUSION<br> METH use resulted in a significant inflammation and necrosis in adipose tissue denoting to the dangers of METH use, when recreationally targeted for weight loss purposes. Methamphetamine, Behaviour, Anxiety, Adipose, Rat 53 59 http://wjps.ir/browse.php?a_code=A-10-576-1&slc_lang=en&sid=1 Fariba Jaafari-Sheybani fjafari3@gmail.com 10031947532846009972 10031947532846009972 No Department of Biology, Shiraz Branch, Islamic Azad University, Shiraz, Iran Seyed-Ebrahim Hosseini ebrahim.hossini@yahoo.com 10031947532846009973 10031947532846009973 Yes Department of Biology, Shiraz Branch, Islamic Azad University, Shiraz, Iran Davood Mehrabani mehrabad@sums.ac.ir 10031947532846009974 10031947532846009974 No Stem Cell Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Amin Derakhshanfar derakhshanfar@sums.ac.ir 10031947532846009975 10031947532846009975 No Diagnostic Laboratory Sciences and Technology Research Center, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran Feridoun Karimi-Busheri fkarimi@ualberta.ca 10031947532846009976 10031947532846009976 No Department of Oncology, University of Alberta, Edmonton, Alberta, Canada