en تخصصي Special مقالات اصيل Original Article <strong>BACKGROUND</strong><br> Given the potential usefulness of Acellular Dermal Matrices (ADM) for wound healing, we aimed to evaluate the stability, histological characteristics, and effectiveness of ADM compared with cryopreserved dermis (CPD) in rat models.<br> <strong>METHODS</strong><br> This experimental study was conducted in the Department of Surgery, Isfahan University of Medical Sciences, Isfahan, Iran, from January to March 2015. The prepared ADM and CPD were transplanted to the full-thickness skin defects on the back of Sprague-Dawley rats. Forty-five days after grafting, the tissues were harvested for histological examination. These two types of the dermis&#39; quality and stability were compared with consideration of the following factors; inflammation, fibroblasts migration, vascularization, collagen formation, capsule formation, and microabscess formation.<br> <strong>RESULTS</strong><br> From 19 selected rates, nine received CPD, and ten were treated with ADM. After transplantation, the mean (SD) weight of ADM and CPD grafts were 1.74 (0.07) and 1.45 (0.77), respectively (<em>P</em><0.001). The frequency of inflammation was significantly higher in CPD grafts (<em>P</em><0.01). Higher grades of collagen organization, fibroblast spreading, and vascularization were more frequent in ADM grafts (<em>P</em><0.01). The frequency of capsule and microabscesses formation was not significantly different between studied groups.<br> <strong>CONCLUSION</strong><br> ADM have a superior effect than CPD in the wound healing process. Both samples had a similar effect in capsule and microabscesses formation and higher costs of ADM preparation. According to the physicians&#39; decision and evaluation of the process&#39;s cost-effectiveness, CPD could be appropriately used as an alternative to ADM. Inflammation, Acellular dermal matrix, Crayopreserved dermis, Collagen, Fibroblasts, Pathological neovascularization 82 88 http://wjps.ir/browse.php?a_code=A-10-466-21&slc_lang=en&sid=1 Mahmood Omranifard 100319475328460010673 100319475328460010673 No Department of Plastic Surgery, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran Mehdi Rasti Ardakani 100319475328460010674 100319475328460010674 No Department of Plastic Surgery, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran Hossein Abdali 100319475328460010675 100319475328460010675 No Department of Plastic Surgery, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran Pejman Mortazavi 100319475328460010676 100319475328460010676 No Department of Pathology, School of Specialize Veterinary Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran Saeed Hoseini 100319475328460010677 100319475328460010677 No Department of Pathology, School of Specialize Veterinary Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran Mohammad Ali Hoghoughi 100319475328460010678 100319475328460010678 Yes Burn and Wound Healing Research Center, Shiraz University of Medical Science, Shiraz, Iran