en تخصصي Special مقالات اصيل Original Article <span style="font-family:Times New Roman;"><span style="font-size:11pt"><span style="line-height:150%"><span calibri=""><b><span style="font-size:12.0pt"><span style="line-height:150%"><span garamond=""><span style="color:black">Background:</span></span></span></span></b><span style="font-size:12.0pt"><span style="line-height:150%"><span garamond=""><span style="color:black"> Single suture craniosynostosis (SSC) is a disorder, affecting brain growth. Reviewing literature reveals controversialists of papers in this field. </span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:150%"><span calibri=""><b><span style="font-size:12.0pt"><span style="line-height:150%"><span garamond=""><span style="color:black">Methods:</span></span></span></span></b><span style="font-size:12.0pt"><span style="line-height:150%"><span garamond=""><span style="color:black"> This prospective study was conducted from 2014 to 2016. All the individuals, aged 2 to 16 years, whose medical records files were complete, with SSC from 1999 to 2013 were included. All patients had undergone cranial vault remodeling at Mofid Hospital, Tehran, Iran. Wechsler questionnaires, WPPSI-III and WISC-IV, were completed for each child based on his/her age. </span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:150%"><span calibri=""><b><span style="font-size:12.0pt"><span style="line-height:150%"><span garamond=""><span style="color:black">Results:</span></span></span></span></b><span style="font-size:12.0pt"><span style="line-height:150%"><span garamond=""><span style="color:black"> Seventy children were included, with the mean age of 6.7 (&plusmn;2.9) years. Forty-six (65.7%) children were boys while 24 (34.3%) were girls. Mean FSIQ for all of children was 95.5 (&plusmn;13.2). Mean verbal IQ, performance IQ, verbal comprehension, perceptual reasoning, processing speed, and working memory are 93.4 (&plusmn;14.1), 96.1 (&plusmn;13.3), 97.5 (&plusmn;13.9), 102.2 (&plusmn;12.5), 94.5 (&plusmn;9.8), and 97.5 (&plusmn;12.9), respectively. There was statistically significant difference between FSIQ of children with SSC and that of unaffected children (<i>P</i>-value<0.05). There was significant difference between verbal IQ of children with SSC and that of unaffected ones (<i>P</i>-value< 0.007). There was significant difference between in processing speed between affected children and unaffected children (<i>P</i>-value<0.012). </span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:150%"><span calibri=""><b><span style="font-size:12.0pt"><span style="line-height:150%"><span garamond=""><span style="color:black">Conclusion:</span></span></span></span></b><span style="font-size:12.0pt"><span style="line-height:150%"><span garamond=""><span style="color:black"> Children, aged 2 to 6 years, with SSC had a significantly lower Verbal IQ, and children, aged 6 to 16 years, with SSC had a significantly lower processing speed than their healthy counterparts. Though FSIQ of children with SSC falls within normal range, it is a little lower than healthy peers. </span></span></span></span></span></span></span><br> &nbsp;</span> IQ, Single suture craniosynostosis, Neurodevelopment, WISC, WPPSI, Wechsler. 57 61 http://wjps.ir/browse.php?a_code=A-10-307-6&slc_lang=en&sid=1 Abdoljalil Kalantar- Hormozi kalantarj@yahoo.com 100319475328460012885 100319475328460012885 Yes Department of Plastic and Craniofacial Surgery, 15 Khordad Hospital, Medical College of Shahid Beheshti University of Medical Science (SBMU), Tehran, Iran Ali Abbaszadeh Kasbi 100319475328460012886 100319475328460012886 No School of Medicine, Tehran University of Medical Sciences (TUMS), Tehran, Iran Hadis Kalantar Hormozi 100319475328460012887 100319475328460012887 No Integrated Program in Neuroscience, McGill University, Montreal, Quebec, Canada Nazanin Rita Davai 100319475328460012888 100319475328460012888 No Clinical Psychiatrist, Private Practice, Tehran, Iran