WORLD JOURNAL OF PLASTIC SURGERY

en Fabrication of Bio -adhesive Gel for Skin Surgery: In Vitro and In Vivo study تخصصي Special مقالات اصيل Original Article Background: Using natural compounds can overcome the disruption of traditional sutures and the problems of tissue adhesives in the wound healing process, the biomedical market has seen many effective skin products but many of them are still have limited. We aimed to use both herbal essential oil and gels to fabricate and study a new oleoresin essential oil of wild pistachio tree Tragacanth resin xerogel-like Bio-adhesive for skin surgery. Its low stiffness, scaffold-based matrix due to the gel part it can facilitate wound healing. Methods: Different concentrations of resin 6-9 w/v and essential oils 0.2 -1 w/v were blended according to the response surface methodology using the central composite design. The attachments were fabricated using the freeze-drying technique. These were assessed physically and biologically cell viability, cell attachment, SEM, FTIR techniques and in vivo a mouse incision injection model. Results: Tragacanth resin is an adhesive agent glue. The gel part could affect the physical properties of attachments including FTIR, the strong peak at 1638.57 cm-1 and Particle size including SEM Mean ±Std Dev; 47 ±0.89 µm. Also, it demonstrated no cytotoxicity towards H-Fib cells, 80% cell viability with good attachment, and cell concentration justified by the gel content. It showed good in vivo biocompatibility.  Conclusion: Fabricated Bio-adhesive gel-like attached with essential oil of wild pistachio content can be a good candidate for regeneration-skin-based surgical purposes. However more in vitro and in vivo revisions are mandatory to adjust the herbal essential oil resin ratio.   Tragacanth, Pistacia Porosity, Cell Survival, Spectroscopy, Fourier Transform Infrared, Tissue Adhesives 0 0 http://wjps.ir/browse.php?a_code=A-10-1034-4&slc_lang=en&sid=1 Hanieh Beiranvand 100319475328460017717 100319475328460017717 No Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran Simin Farokhi 100319475328460017718 100319475328460017718 No USERN Office, Lorestan University of Medical Sciences, Khorramabad, Iran Bahram Rasoulian 100319475328460017719 100319475328460017719 No Neurophysiology Research Center, Institute of Neuroscience and Cognition and Department of Physiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Sodabeh Zare 100319475328460017720 100319475328460017720 No Nutritional Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran Farzaneh Chehelcheraghi Chehelcheraghi.farzaneh@sbmu.ac.ir 100319475328460017721 100319475328460017721 Yes Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Marzieh Rashidipour 100319475328460017722 100319475328460017722 No Nutritional Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran.