en تخصصي Special مقالات اصيل Original Article <span style="font-size:11pt"><span style="line-height:150%"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:12.0pt"><span style="line-height:150%"><span style="font-family:&quot;Times New Roman&quot;,serif">Background</span></span></span></b><span style="font-size:12.0pt"><span style="line-height:150%"><span style="font-family:&quot;Times New Roman&quot;,serif">: Migraine is a chronic and debilitating disease that, despite therapeutic advances, many patients do not respond to conventional treatments. Surgeries such as neurolysis and neurectomy of the greater occipital nerve (GON) have been proposed as surgical options for treating these patients. We aimed to compare the effectiveness of these two methods in reducing symptoms of chronic treatment-resistant migraine.</span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:150%"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:12.0pt"><span style="line-height:150%"><span style="font-family:&quot;Times New Roman&quot;,serif">Methods</span></span></span></b><span style="font-size:12.0pt"><span style="line-height:150%"><span style="font-family:&quot;Times New Roman&quot;,serif">: This study was conducted as a randomized, prospective clinical trial. Ten patients with chronic treatment-resistant migraine were divided into neurolysis and neurectomy groups. Primary and secondary outcomes including pain intensity using the Visual Analog Scale (VAS), migraine-related disability using the Migraine Disability Assessment (MIDAS) questionnaire, and headache impact on quality of life using the Headache Impact Test (HIT-6) questionnaire were evaluated at intervals of one month, three months, and six months after surgery. </span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:150%"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:12.0pt"><span style="line-height:150%"><span style="font-family:&quot;Times New Roman&quot;,serif">Results</span></span></span></b><span style="font-size:12.0pt"><span style="line-height:150%"><span style="font-family:&quot;Times New Roman&quot;,serif">: No significant difference was observed between the neurolysis and neurectomy groups in HIT-6, MIDAS scores, and pain intensity (VAS) at any of the measurement times (<i>P</i>-value>0.05). Also, using the Friedman test, no significant difference was observed between the three measurement stages in either group (P-value>0.05). For both pain intensity (VAS) and MIDAS variables, the changes observed over time were not significant, and there was no significant difference between the two groups at any time point.</span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:150%"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:12.0pt"><span style="line-height:150%"><span style="font-family:&quot;Times New Roman&quot;,serif">Conclusion</span></span></span></b><span style="font-size:12.0pt"><span style="line-height:150%"><span style="font-family:&quot;Times New Roman&quot;,serif">: Both neurolysis and neurectomy methods might be considered as effective treatment options for patients with chronic treatment-resistant migraine. Personalized treatment and team decision-making are helpful in selecting the appropriate surgical method for patients with chronic migraine. </span></span></span></span></span></span><br> &nbsp; Neurectomy, Neurolysis, Migraine, Surgery 0 0 http://wjps.ir/browse.php?a_code=A-10-1124-3&slc_lang=en&sid=1 Fatemeh Samiei 100319475328460017918 100319475328460017918 Yes Department of Plastic & Reconstructive Surgery, Shahid Beheshti University of Medical Sciences, Tehran, Iran Hojjat Molaei 100319475328460017919 100319475328460017919 No Department of Plastic & Reconstructive Surgery, Tehran University of Medical Sciences, Tehran, Iran Mansoureh Togha 100319475328460017920 100319475328460017920 No Headach Department, Iranian Center of Neurological Research, Sina Hospital , Tehran University of Medical Sciences, Tehran, Iran. Hamidreza Fathi 100319475328460017921 100319475328460017921 No Department of Plastic & Reconstructive Surgery, Tehran University of Medical Sciences, Tehran, Iran Ali Yavari 100319475328460017922 100319475328460017922 No Department of Plastic & Reconstructive Surgery, Tehran University of Medical Sciences, Tehran, Iran Changiz Delavari 100319475328460017923 100319475328460017923 No Department of Plastic & Reconstructive Surgery, Tehran University of Medical Sciences, Tehran, Iran Abbas Tafakhori 100319475328460017924 100319475328460017924 No Iranian Center of Neurological Research (ICNR), Neuroscience Institute, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran