en تخصصي Special مقالات اصيل Original Article <span style="font-size:11pt"><span style="line-height:150%"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:12.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">Background: </span></span></span></b><span style="font-size:12.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">Hemorrhage during rhinoplasty may impair the surgeon&#39;s visibility.. Our objective was to examine the impact of subcutaneously administered Tranexamic acid (TXA) on bleeding during rhinoplasty.</span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:150%"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:12.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">Methods: </span></span></span></b><span style="font-size:12.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">A three-blind randomized clinical trial including 60 patients undergoing nose surgery was conducted to compare the effects of two different anesthetic solutions on surgery results. The control group received a solution consisting of 5 cc of 2% lidocaine and 0.5 cc of epinephrine, and the TXA group received a solution containing 5 ml of 2 lidocaine, 0.25 cc of epinephrine and 4.75 cc of 10% TXA. To achieve a total injection volume of 10 ml in both groups, distilled water was added. Bleeding rate, hemodynamic parameters, surgeon satisfaction and overall quality of the surgical field were evaluated.</span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:150%"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:12.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">Results</span></span></span></b><span style="font-size:12.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">: The hemodynamic parameters exhibited no notable differences between the two groups throughout the study period (<i>P</i> value > 0.05). The volume of bleeding observed in the TXA group was marginally greater than that in the control group (<i>P</i> value=0.061). Additionally, there were no significant variations in the quality of the surgical field or the satisfaction levels of the surgeon between the two groups.</span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:150%"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:12.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">Conclusion</span></span></span></b><span dir="RTL" lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">:</span></span></span><b>&nbsp; </b><span style="font-size:12.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">In the TXA group, there was no increase in bleeding despite using a low concentration of epinephrine. Consequently, it is recommended that an injectable formulation of TXA containing a reduced concentration of epinephrine be used in surgical procedures where the use of high-concentration epinephrine is contraindicated, such as in patients with cardiovascular disease.</span></span></span></span></span></span><br> &nbsp; Bleeding, Rhinoplasty, Tranexamic Acid 66 74 http://wjps.ir/browse.php?a_code=A-10-962-2&slc_lang=en&sid=1 Mehrdad Adibparsa 100319475328460016199 100319475328460016199 No Department of Surgery, Isfahan University of Medical Sciences, Isfahan, Iran Mina Ghazavi 100319475328460016200 100319475328460016200 No Department of Anesthesiology, Isfahan University of Medical Sciences, Isfahan, Iran Hamidreza Shetabi hamidshetabi@med.mui.ac.ir 100319475328460016201 100319475328460016201 Yes Anesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran