en تخصصي Special مقالات اصيل Original Article <span style="font-size:11pt"><span style="line-height:150%"><span arial="" style="font-family:"><b><span style="font-size:12.0pt"><span style="line-height:150%"><span garamond="" style="font-family:">Background: </span></span></span></b><span style="font-size:12.0pt"><span style="line-height:150%"><span garamond="" style="font-family:">Adjuvant-induced autoimmune syndrome (ASIA), described in 2011, includes autoimmune reactions triggered by environmental adjuvants, such as silicone breast implants (SBI). Symptoms include fatigue, sleep disturbances, appetite changes, muscle pain, fever, among others, with pathophysiology involving a combination of genetic predisposition and adjuvant exposure, leading to abnormal immune responses. We aimed to define clinical profiles and outcomes of patients with SBI, clarify ASIA&#39;s clinical implications, and guide future research.</span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:150%"><span arial="" style="font-family:"><b><span style="font-size:12.0pt"><span style="line-height:150%"><span garamond="" style="font-family:">Methods:</span></span></span></b><span style="font-size:12.0pt"><span style="line-height:150%"><span garamond="" style="font-family:"> Using the PRISMA-ScR framework, a scoping review was conducted to identify clinical profiles, preexisting conditions, prosthetic anomalies, and outcomes of patients with ASIA syndrome associated with SBI. Searches were performed in Medline, Scopus, Lilacs, and Google Scholar to locate relevant studies.</span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:150%"><span arial="" style="font-family:"><b><span style="font-size:12.0pt"><span style="line-height:150%"><span garamond="" style="font-family:">Results:</span></span></span></b><span style="font-size:12.0pt"><span style="line-height:150%"><span garamond="" style="font-family:"> Of 35 selected studies, 21 were case reports, 6 case series, and 8 cohort studies, identifying 848 patients, predominantly from the Netherlands (n=513), with an average age of 45-47 yr. Common medical histories included autoimmune diseases and breast cancer, while frequent implant-related anomalies were capsular contracture and rupture. Musculoskeletal symptoms and fatigue were the most prevalent, and implant explantation was the primary treatment, resulting in symptom improvement for most patients.</span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:150%"><span arial="" style="font-family:"><b><span style="font-size:12.0pt"><span style="line-height:150%"><span garamond="" style="font-family:">Conclusion: </span></span></span></b><span style="font-size:12.0pt"><span style="line-height:150%"><span garamond="" style="font-family:">This review highlights the clinical features of ASIA syndrome in patients with SBI, particularly musculoskeletal symptoms, fatigue, and the presence of positive antinuclear antibody as a potential marker. However, the relationship between SBI and ASIA remains controversial. Despite limitations in current evidence, ongoing clinical monitoring and further research are crucial to better understanding and managing ASIA syndrome in patients with SBI.</span></span></span></span></span></span><br> &nbsp; Adjuvant-induced autoimmune syndrome (ASIA), ASIA syndrome, Breast implants, Plastic surgery, Scoping review 11 20 http://wjps.ir/browse.php?a_code=A-10-1064-2&slc_lang=en&sid=1 Ospina-Gómez Juan Esteban juanestebanospina98@gmail.com 100319475328460017001 100319475328460017001 Yes Research Department, FOSCAL, Floridablanca, Colombia. Latorre-Arévalo María Gabriela 100319475328460017002 100319475328460017002 No Research Department, FOSCAL, Floridablanca, Colombia. Ayala-Gutierrez María Camila 100319475328460017003 100319475328460017003 No Research Department, FOSCAL, Floridablanca, Colombia. Monsalve-Suárez Edgar Felipe 100319475328460017004 100319475328460017004 No Research Department, FOSCAL, Floridablanca, Colombia. Amaya-Muñoz María Camila 100319475328460017005 100319475328460017005 No Research Department, FOSCAL, Floridablanca, Colombia. Caceres-Ramírez Catalina 100319475328460017006 100319475328460017006 No Research Department, FOSCAL, Floridablanca, Colombia. Alviar-Rueda Juan Darío 100319475328460017007 100319475328460017007 No Research Department, FOSCAL, Floridablanca, Colombia. Camacho-López Paul Anthony 100319475328460017008 100319475328460017008 No Research Department, FOSCAL, Floridablanca, Colombia.