en تخصصي Special مقالات اصيل Original Article <span style="font-size:11pt"><span style="line-height:150%"><span style="text-autospace:none"><span calibri="" style="font-family:"><b><span style="font-size:12.0pt"><span style="line-height:150%"><span garamond="" style="font-family:"><span style="color:black">Background</span></span></span></span></b><span style="font-size:12.0pt"><span style="line-height:150%"><span garamond="" style="font-family:"><span style="color:black">: Diabetes mellitus is related to wound healing process impairments and molecular abnormalities of the wound.</span></span></span></span><span style="font-size:12.0pt"><span style="line-height:150%"><span garamond="" style="font-family:"> We aimed <span style="color:black">to evaluate the therapeutic potential of semi-solid bone marrow as a source of stem cells (SCs) in regenerative medicine. </span></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:150%"><span style="text-autospace:none"><span calibri="" style="font-family:"><b><span style="font-size:12.0pt"><span style="line-height:150%"><span garamond="" style="font-family:"><span style="color:black">Methods:</span></span></span></span></b><span style="font-size:12.0pt"><span style="line-height:150%"><span garamond="" style="font-family:"><span style="color:black"> This trial study was conducted at the Faculty of Medicine, Lorestan University of Medical Sciences, Khorram Abad, IRAN in 2019. Forty five Albino Wistar rats with an average weight of 250&ndash;300g, were purchased from Lorestan Aftabavaran Company in (Khorramabad, Lorestan, Iran). The rats were divided into 3 groups (n=15). For all groups, Streptozotocin (STZ) (Single dosage; 65 mg/kg, i.p.) was used to induce diabetes, and Sharp dissection was used to draw and pull down a dorsal skin flap (9&times;3 cm) in the control and saline groups</span></span></span></span><span style="font-size:12.0pt"><span style="line-height:150%"><span garamond="" style="font-family:"> <span style="color:black">on day0, respectively.</span> <span style="color:black">The group used 7 &times; 10⁹ BMMSCs on day 0.</span> <span style="color:black">Histologic specimens were stained with hematoxylin and eosin and were stained with trichrome mason. Biomechanic measurements were taken in the wound area, </span></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:150%"><span style="text-autospace:none"><span calibri="" style="font-family:"><b><span style="font-size:12.0pt"><span style="line-height:150%"><span garamond="" style="font-family:"><span style="color:black">Results: </span></span></span></span></b><span style="font-size:12.0pt"><span style="line-height:150%"><span garamond="" style="font-family:"><span style="color:black">The epidermal thickness was increasing and blood vessels were growing.</span></span></span></span><span style="font-size:12.0pt"><span style="line-height:150%"><span garamond="" style="font-family:"> <span style="color:black">In the cells group, hair follicle destruction, cellular penetration, diffuse fibrosis, and necrosis were not observed in comparison with the saline and control groups. The Cells group had a higher energy absorption than the Bending stiffness and Maximal Force Ultimate Tensile Strength (UTS) group on day 14 as a result of decreased Bending stiffness and Maximal Force Ultimate Tensile Strength (UTS).</span></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:150%"><span style="text-autospace:none"><span calibri="" style="font-family:"><b><span style="font-size:12.0pt"><span style="line-height:150%"><span garamond="" style="font-family:"><span style="color:black">Conclusion:</span></span></span></span></b> <span style="font-size:12.0pt"><span style="line-height:150%"><span garamond="" style="font-family:"><span style="color:black">According on result of recent study, Stem cells can improve the healing of diabetic incision wounds.</span></span></span></span></span></span></span></span><br> &nbsp; Streptozocin, Tensile Strength, Bone Marrow, Biomechanical Phenomena, Regenerative Medicine, Wound Healing, Collagen, Mesenchymal Stem Cells, Necrosis, Diabetes Mellitus 63 71 http://wjps.ir/browse.php?a_code=A-10-1034-2&slc_lang=en&sid=1 Maryam Habibi 100319475328460017028 100319475328460017028 No 1. Student Research Committee, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran Jafar Rezaian 100319475328460017029 100319475328460017029 No 2. Department of Anatomical Sciences, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran Pooria Ali 100319475328460017030 100319475328460017030 No 3. Department of Cardiology, School of Medicine, Shahid Madani Hospital Lorestan University of Medical Sciences, Khorramabad, Iran Rasool Mohammedi 100319475328460017031 100319475328460017031 No 4. Department of Biostatistics and Epidemiology, School of Health and Nutrition, Nutritional Health Research Center, Mehr Psychiatric Hospital, Shahid Madani Hospital Lorestan University of Medical Sciences, Khorramabad, Iran Hassan Ahmadvand 100319475328460017032 100319475328460017032 No 5. Clinical Biochemistry Molecular Research Center, Institute of Mental Health and Addiction Hamadan University of Medical Sciences, Hamadan, Iran Abolfazl Abaszadeh 100319475328460017033 100319475328460017033 No 6. Department of Plastic and Reconstructive surgery, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Farzaneh Chehelcheraghi fr.chehelcheraghi@gmail.com 100319475328460017034 100319475328460017034 Yes 7. Medical Ethics and Law Research Center, Research Institute of Functional Neurosurgery, Shahid Beheshti University of Medical Sciences, Tehran, I.R. Iran