WORLD JOURNAL OF PLASTIC SURGERY
مجله جهانی جراحی پلاستیک
WJPS
Medical Sciences
http://wjps.ir
1
admin
2228-7914
2252-0724
8
10.61186/wjps
14
8888
13
en
jalali
1397
1
1
gregorian
2018
4
1
7
2
online
1
fulltext
en
Comparison of Intralesional Triamcinolone Acetonide, 5-Fluorouracil, and Their Combination in Treatment of Keloids
تخصصي
Special
مقالات اصيل
Original Article
<p style="margin-left:14.2pt;"><strong>BACKGROUND</strong><br>
Despite the myriad options available, there is no universally accepted treatment for keloids. This study has compared intralesional triamcinolone acetonide, 5-fluorouracil, and their combination in treatment of keloids.<br>
<strong>METHODS</strong><br>
In this randomized parallel group study, 60 patients were enrolled and randomly allocated to three groups. Patients received intralesional injections of triamcinolone acetonide (TAC) in Group TAC, 5-fluorouracil (5FU) in Group 5FU and a combination in Group T+F every 3 weeks till 24 weeks or till the keloid resolved. <br>
<strong>RESULTS</strong><br>
There was a reduction in all parameters at every successive assessment in all three groups. Improvement in terms of height, vascularity and pliability was fastest with 5FU, TAC and T+F group, respectively, which was statistically significant. Decrease in pigmentation was significantly faster with T+F. Reduction in pruritus, however, was significantly faster with 5FU than the other groups, but the difference in reduction of pain among the three groups was not significant. Telangiectasias and skin atrophy were seen most commonly in TAC group, while skin ulceration was a common problem in 5FU group.<br>
<strong>CONCLUSION</strong><br>
TAC, 5FU and their combination are all effective in keloid scars. A combination of TAC+5FU seems to offer the balanced benefit of faster and more efficacious response with lesser adverse effects when compared to individual drugs.</p>
<p style="margin-left:14.2pt;"></p><p style="margin-left:14.2pt;"></p>
Keloid, Triamcinolone, Fluorouracil
212
219
http://wjps.ir/browse.php?a_code=A-10-292-1&slc_lang=en&sid=1
Sunil
Srivastava
drsunilsrivastava@yahoo.co.in
10031947532846006137
10031947532846006137
No
Sawai Man Singh Medical College and Hospital, Jaipur
Aditya
Patil
drpatiladitya@gmail.com
10031947532846006138
10031947532846006138
Yes
Sawai Man Singh Medical College and Hospital, Jaipur
Chaitra
Prakash
drpchaitra@gmail.com
10031947532846006139
10031947532846006139
No
Sawai Man Singh Medical College and Hospital, Jaipur
Hiranmayi
Kumari
jhahiranmayi@gmail.com
10031947532846006140
10031947532846006140
No
Sawai Man Singh Medical College and Hospital, Jaipur