WORLD JOURNAL OF PLASTIC SURGERY
مجله جهانی جراحی پلاستیک
WJPS
Medical Sciences
http://wjps.ir
1
admin
2228-7914
2252-0724
8
10.61186/wjps
14
8888
13
en
jalali
1396
10
1
gregorian
2018
1
1
7
1
online
1
fulltext
fa
Tissue Engineering in Maxillary Bone Defects
عمومى
General
مقالات اصيل
Original Article
<strong>BACKGROUND</strong><br>
Restoration of craniofacial bone defects has been a concern for oral and maxillofacial surgeons. In this study, the healing effect of fibrin glue scaffold was compared with autologous bone graft in mandibular defects of rabbit.<br>
<strong>METHODS</strong><br>
Bilateral unicortical osteotomy was performed in the diastema region of 10 male Dutch rabbits. The subjects were randomly divided into 2 equal groups. The mandibular defect on the right side was treated with fibrin glue scaffold and the defect on the left side with autologous bone graft provided from iliac crest. After 4 and 8 weeks, five rabbits from each group were sacrificed and the defects were evaluated morphologically, by coronal computed tomography scanning (CT-scan) and by histological examinations.<br>
<strong>RESULTS</strong><br>
The healing effect of fibrin glue scaffold and autologous bone graft was similar with appropriate osteogenesis in comparison to the control group.<br>
<strong>CONCLUSION</strong><br>
Using fibrin glue can be a non-invasive treatment of choice in mandibular defects and maxillofacial surgeries when compared with autologous bone graft.
Fibrin glue, Scaffold, Autologous bone graft, Mandibular defect, Rabbit
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http://wjps.ir/browse.php?a_code=A-10-1-67&slc_lang=fa&sid=1
Azizollah
Khodakaram-Tafti
10031947532846005039
10031947532846005039
No
Department of Pathobiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran
Davood
Mehrabani
mehrabanittrc@gmail.com
10031947532846005040
10031947532846005040
Yes
Stem Cell Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Hanieh
Shaterzadeh-Yazdi
10031947532846005041
10031947532846005041
No
Department of Pathobiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran
Barbad
Zamiri
10031947532846005042
10031947532846005042
No
Department of Craniomaxillofacial Surgery, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran
Mahsa
Omidi
10031947532846005043
10031947532846005043
No
Department of Oral and Maxillofacial Radiology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran