WORLD JOURNAL OF PLASTIC SURGERY
مجله جهانی جراحی پلاستیک
WJPS
Medical Sciences
http://wjps.ir
1
admin
2228-7914
2252-0724
8
10.61186/wjps
14
8888
13
en
jalali
1397
10
1
gregorian
2019
1
1
8
1
online
1
fulltext
en
The Effect of Topical Vitamin A and E on Ischemic Random Skin Flap Survival
عمومى
General
مقالات اصيل
Original Article
BACKGROUND<br>
Ischemia of skin flaps is an important complication in reconstructive surgery. This study evaluated the efficacy of topical vitamins A and E on improving flap survival. <br>
METHODS<br>
Twenty-four white-albino male rats were randomly divided into two groups of treatment and control. Standard rectangular, distally based dorsal random pattern skin flap was elevated. Intra-peritoneal cephazoline was administered to prevent any unexpected infection. No pharmaceutical agent was administered for the control group, but pure vaseline ointment. In treatment group, vaseline plus vitamins A and E were administrated daily after surgery for 10 days. The rats were evaluated on the 10th day after surgery for viable and necrotic portions of the flaps. <br>
RESULTS<br>
The mean values of necrosis in the flaps were 625±189.56 and 920.00±247.31 in the treatment and control groups, respectively. Vaseline plus vitamins increased flap survival significantly. CONCLUSION<br>
Topical vitamins A and E may be effective pharmaceutical agents to increase viability of random skin flaps in rats. They can be added to vasoactive topical agents to reach better results.
Vitamin A, Vitamin E, Ischemia, Skin flap, Survival, Rat
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61
http://wjps.ir/browse.php?a_code=A-10-200-2&slc_lang=en&sid=1
Seyed Esmail
Hassanpour
hassanpour1394@sbmu.ac.ir
10031947532846006481
10031947532846006481
No
professor of plastic &reconstructive surgery, medicine school, TShahid Beheshti University of Medical Sciences, Tehran, Iran
Khalil
Rostami
k.rostami@yagoo.com
10031947532846006482
10031947532846006482
No
assistant professor of plastic &reconstructive surgery, medicine school, TShahid Beheshti University of Medical Sciences, Tehran, Iran
Eznollah
Azargashb
10031947532846006483
10031947532846006483
No
Assistant Professor of Departmen of community medicine,School of medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Kourosh
Saberi
10031947532846006484
10031947532846006484
No
Assistant Professor of plastic & reconstructive surgery .Semnan University of Medical Sciences, Semnan, Iran
Seyyed Hosein
Hamraz
10031947532846006485
10031947532846006485
No
Aassistant professor of plastic &reconstructive sushahid Beheshti University of Medical Sciences, Tehran, Iran
Fatemeh
Farajzadeh Vajari
fatemeh_582003@yahoo.com
10031947532846006486
10031947532846006486
No
Gynecologist surgeon, Privat practice , Tehran, Iran
Hojjat
Molaei
hmggprs@gmail.com
10031947532846006487
10031947532846006487
Yes
Aassistant professor of plastic &reconstructive surgery, medicine school, Tehran University of Medical Sciences, Tehran, Iran