WORLD JOURNAL OF PLASTIC SURGERY
مجله جهانی جراحی پلاستیک
WJPS
Medical Sciences
http://wjps.ir
1
admin
2228-7914
2252-0724
8
10.61186/wjps
14
8888
13
en
jalali
1398
10
1
gregorian
2020
1
1
9
1
online
1
fulltext
en
Montelukast for Medical Delay in Flap Surgery
تخصصي
Special
مقالات اصيل
Original Article
<strong>BACKGROUND</strong><br>
Delay phenomenon can be used for better blood supply of the flap in plastic surgery. Effects of Montelukast have been observed to reduce ischemia/reperfusion injury in various organs due to angiogenic and anti-oxidant effects. The present study aimed to determine the role of Montelukast as medical delay of the flaps.<br>
<strong>METHODS</strong><br>
In this experimental study, 42 Wistar rats were divided into 3 equal groups. These groups were Surgical Delay Group (SDG), Medical Delay Group (MDG) and Control Group (CG). In SDG, 8×3 cm rectangular randomized random skin flap was first surgically delayed at rats’ back. The MDG received 10 mg/kg oral Montelukast via orogastric tube for 5 days as medical delay. In MDG and SDG flap, harvesting was undertaken after a delayed period, but there was not any delayed period in CG. After delayed period, a segment of the skin flap was biopsied for assessing angiogenesis. After 14<sup>th</sup> days, the photos were taken and the size of the necrotic area of the flap was measured.<br>
<strong>RESULTS</strong><br>
A significant difference was observed between the mean survival and angiogenesis (<em>p</em>=0.002). The same performance was reported between MDG and SDG, which were alike regarding survival and angiogenesis (<em>p</em>>0.05); while there was a significant difference between the control and surgical groups, as well as control and medical groups (<em>p</em><0.05). Finally, the inflammation showed no significant difference (<em>p</em>>0.05).<br>
<strong>CONCLUSION</strong><br>
Regarding positive effects of Montelukast on survival and angiogenesis, it is recommended to be used as a medication for larger studies.
Flaps, Medical delay, Montelukast
48
54
http://wjps.ir/browse.php?a_code=A-10-51-2&slc_lang=en&sid=1
Maryam
Iranpour
miranpour@kmu.ac.ir
10031947532846007666
10031947532846007666
No
Department of Pathology, Pathology and Stem Cell Research Center, Kerman University of Medical Sciences, Kerman, Iran
Ali
Khodarahmi
khodarahmiali@yahoo.com
10031947532846007667
10031947532846007667
Yes
Department of Surgery, Pathology and Stem Cell Research Center, Kerman University of Medical Sciences, Kerman, Iran
Nima
Khodarahmi
khodarahminima@yahoo.com
10031947532846007668
10031947532846007668
No
Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran
Mohammad
Shafiee
khodarahmiali@yahoo.com
10031947532846007669
10031947532846007669
No
Assistant Professor of Surgery HPB and Transplant Surgeon, Afzalipoor Hospital , Kerman
Reza
Malekpourafshar
khodarahmiali@yahoo.com
10031947532846007670
10031947532846007670
No
Department of Pathology, Pathology and Stem Cell Research Center, Kerman University of Medical Sciences, Kerman, Iran
Nozar
Nakhaee
khodarahmiali@yahoo.com
10031947532846007671
10031947532846007671
No
Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran