WORLD JOURNAL OF PLASTIC SURGERY
مجله جهانی جراحی پلاستیک
WJPS
Medical Sciences
http://wjps.ir
1
admin
2228-7914
2252-0724
8
10.61186/wjps
14
8888
13
en
jalali
1399
11
1
gregorian
2021
2
1
10
2
online
1
fulltext
en
The Role of Recombinant Fibroblast Growth Factor 1 in Enhancing the Angiogenesis in Random Cutaneous Flaps in Animal Model of Rat
تخصصي
Special
مقالات اصيل
Original Article
BACKGROUND<br>
Randomized skin flaps have been used as a basic treatment modality for covering skin defects for a long time but they have always been in the risk of an inherent ischemia. Fibroblast growth factor 1 is a known angiogenic factor in in vitro studies which has shown conflicting results in in vivo investigation. We aimed to determine the effect of recombinant fibroblast growth factor on the angiogenesis rate of random cutaneous flap in animal model of rats.<br>
METHODS<br>
This experimental study was conducted on 24 adult male rats randomized to 2 groups. In the first group FGF1 was injected subdermally in equally divided doses and distances of random flap surface in days 1, 3 and 5. In second group, normal saline was injected as control. Flap surgery was done on day 21 after first injection. The extent of necrosis and angiogenesis (mean vessel density) were assessed in day 14 after surgery.<br>
Results<br>
The mean percentage of clinically apparent necrosis was 35.2% (±10.5) in intervention (FGF1) group and 38.1% (±8.7) in control (normal saline), re-spectively. Mean vessel density was 86.20±5.6/mm2 in control group and 90.17±5.5/mm2 in intervention group, which showed no statistically signifi-cant difference.<br>
CONCLUSION<br>
Mean vessel density and mean percentage of clinically apparent necrosis area were similar in 2 groups of rats with random cutaneous flaps receiving FGF1 or normal saline.
Fibroblast growth factor 1, Angiogenesis, Random skin flap
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81
http://wjps.ir/browse.php?a_code=A-10-270-2&slc_lang=en&sid=1
Hossein
Akbari
100319475328460010633
100319475328460010633
Yes
Department of Plastic and Recon-structive Surgery, School of Medi-cine, Iran University of Medical Sci-ences (IUMS), Tehran, Iran
Mehdi
Ahmadi
100319475328460010634
100319475328460010634
No
Department of Plastic and Recon-structive Surgery, School of Medi-cine, Iran University of Medical Sci-ences (IUMS), Tehran, Iran
Mohammad Javad
Fatemi
100319475328460010635
100319475328460010635
No
Department of Plastic and Recon-structive Surgery, School of Medi-cine, Iran University of Medical Sci-ences (IUMS), Tehran, Iran
Ali
Foroutan
100319475328460010636
100319475328460010636
No
Department of Plastic and Recon-structive Surgery, School of Medi-cine, Iran University of Medical Sci-ences (IUMS), Tehran, Iran
Peyman
Akbari
100319475328460010637
100319475328460010637
No
Department of Plastic and Recon-structive Surgery, School of Medi-cine, Iran University of Medical Sci-ences (IUMS), Tehran, Iran
Hossein
Bagheri
100319475328460010638
100319475328460010638
No
Department of Anesthesiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Majid
Golkar
100319475328460010639
100319475328460010639
No
Department of Parasitology, Pasteur Institute of Iran, Tehran, Iran