en تخصصي Special مقالات اصيل Original Article BACKGROUND<br> This study was designed for the evaluation of Acellular Dermal Matrix (ADM) as a scaffold for adipose-derived stem cell transferring in the rat model.<br> METHODS<br> This experimental study was done in the Burn Research Center of Iran University of Medical Sciences and Bonyakhteh Research Center, Tehran, Iran according to the standards of laboratory animals. Overall, 26 healthy Sprague-Dawley rats were used. Two of them were used to prepare ADM. In group one, the first wound on each, rat was spread with the mixture of fibrin gel and autologous stem cell. Only the stem cells combined with fibrinogen were spread on the other wound. In group two, the first wound on each rat was covered only with ADM, and the second wound was covered with gauze Vaseline. To perform sampling we used observation and photography at 7-30 days. Overall, 48 samples were taken of all the rats using skin punch biopsy on the 30th day for histopathology evaluation.<br> RESULTS<br> There were significant differences in each group; however, the difference between different groups on days was not significant. In pathology, epithelialization, vascularization, the amount of collagen, collagen arrangement, the number of fibroblasts, and inflammation indices were investigated. The total score in each group was used for analysis. In statistical analysis, there was no pathology score difference among groups.<br> CONCLUSION<br> Using stem cells with or without ADM could not enhance the process of wound healing or improve pathology indices. Stem cell, Tissue engineering, Acellular Dermis 67 75 http://wjps.ir/browse.php?a_code=A-10-270-3&slc_lang=en&sid=1 Maryam Jahanian 100319475328460010608 100319475328460010608 No Burn Research Center, Hazrat Fatima Hospital, Rehabilitation Research Center, School of Rehabilitation Sci-ences, Iran University of Medical Sciences, Tehran, Iran. Sara Hoseini 100319475328460010609 100319475328460010609 No Burn Research Center, Rajaie Cardi-ovascular Medical and Research Cen-ter, Iran University of Medical Sci-ences, Tehran, Iran Amir Atashi 100319475328460010610 100319475328460010610 No Stem Cell and Tissue Engineering Research Center, Shahroud Universi-ty of Medical Sciences, Shahroud, Iran. Mohsen Saberi 100319475328460010611 100319475328460010611 No Community Medicine, Quran and Hadis Research Center, Faculty of Medicine, Baqiyatallah University of Medical Sciences Tehran, Iran. Seyyed Aboozar Hoseini 100319475328460010612 100319475328460010612 No Burn Research Center, Hazrat Fatima Hospital, Iran University of Medical Sciences, Tehran, Iran. Kambiz Mozaffari 100319475328460010613 100319475328460010613 No Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran. Mohammad Javad Fatemi mjfatemi41@gmil.com 100319475328460010614 100319475328460010614 Yes Department of Plastic & Reconstruc-tive Surgery, Burn Research Center, Hazrat Fatima Hospital Iran Universi-ty of Medical Sciences, Tehran, Iran.