en تخصصي Special مقالات اصيل Original Article <strong>BACKGROUND</strong><br> Surgical antibiotic prophylaxis has been widely used for prevention of surgical site infections (SSI&rsquo;s). World Health Organization (WHO) global guidelines strongly recommend the administration of pre-operative prophylactic antibiotic, depending on the type of surgery, to reduce SSI&rsquo;s. However, within Gulf Cooperation Council (GCC) countries, antibiotic resistance has been rising due to unregulated prescribing practice. We aimed to assess adherence to local/international guidelines in the plastic surgery unit of Salmaniya Medical Complex.<br> <strong>METHODS</strong><br> This study was a retrospective review of adults&rsquo; undergoing plastic surgery between the dates of 1^st of January 2019 to 30^th of April 2019. Recommendations and guidelines were provided by South Australian Guidelines for Surgical Antimicrobial Prophylaxis, NHS Greater-Glasgow Foundation Trust. &nbsp;Salmaniya Medical Complex Guidelines were also taken into consideration. This was followed by an implementation of standardized guidelines and a re-assessment period for another four months.<br> <strong>RESULTS</strong><br> There were 106 patients who met the inclusion/exclusion criteria throughout the primary cohort. With respect to choice and dose of antibiotics, only 21 (19.8%) of the procedures were adherent to global/local guidelines. Similarly, only 11.5% of those cases have met the recommended timing for pre-operative antibiotic administration. After the implementation period, adherence to guidelines regarding choice and time of antibiotic administration has increased to 36.8% and 32.6% respectively. SSI decreased from 1.8% to 0.08%.<br> <strong>CONCLUSION</strong><br> Practice in SMC in plastic surgery pre-operative antibiotic prophylaxis shows poor compliance to both local and international guidelines in terms of choice, dose, and time of administration. We were able to significantly improve adherence to international/local practice in both areas by implementing an integrated protocol in liaison with the medical staff involved in the plastic surgery unit and operating theatres. Plastic surgery, Surgical site infections, Wound infections, Guidelines, Protocol, Aesthetic, Antibiotic prophylaxis 54 62 http://wjps.ir/browse.php?a_code=A-10-671-2&slc_lang=en&sid=1 Isa AlAlwani 100319475328460011625 100319475328460011625 Yes Department of Plastic Surgery, Salmaniya Medical Complex, Manama, Kingdom of Bahrain Hasan AlTahoo 100319475328460011626 100319475328460011626 No Department of Plastic Surgery, Salmaniya Medical Complex, Manama, Kingdom of Bahrain Fatima Yaqoob 100319475328460011627 100319475328460011627 No Department of Plastic Surgery, Salmaniya Medical Complex, Manama, Kingdom of Bahrain Fatema Ahmed Ali 100319475328460011628 100319475328460011628 No Department of Plastic Surgery, Salmaniya Medical Complex, Manama, Kingdom of Bahrain Sadeq Alekri 100319475328460011629 100319475328460011629 No Department of Plastic Surgery, Salmaniya Medical Complex, Manama, Kingdom of Bahrain