WORLD JOURNAL OF PLASTIC SURGERY
مجله جهانی جراحی پلاستیک
WJPS
Medical Sciences
http://wjps.ir
1
admin
2228-7914
2252-0724
8
10.61186/wjps
14
8888
13
en
jalali
1401
4
1
gregorian
2022
7
1
11
2
online
1
fulltext
en
Is Preemptive Oral Tizanidine Effective on Postoperative Pain Intensity after Bimaxillary Orthognathic Surgery? A Triple-Blind Randomized Clinical Trial
تخصصي
Special
مقالات اصيل
Original Article
<span style="font-family:Times New Roman;"><span style="font-size:11pt"><span style="line-height:150%"><span calibri=""><b><span garamond="">Background</span></b><span garamond="">: We aimed to investigate the effect of preoperative administration of oral tizanidine on postoperative pain intensity after bimaxillary orthognathic surgery.</span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:150%"><span calibri=""><b><span garamond="">Methods</span></b><span garamond="">: <span style="color:black">All healthy skeletal class III patients who were candidates </span>for bimaxillary orthognathic surgery were enrolled in this triple-blind randomized clinical trial. The study was carried out in the Maxillofacial Surgery Department of Qaem Hospital, Mashhad, Iran; from January 2021 to November 2021.</span> <span garamond="">The consecutive patients were randomly divided into tizanidine and placebo groups. One hour prior to anesthesia induction, the tizanidine group received 4 mg Tizanidine dissolved in 10 ml apple juice, whereas the placebo group received an identical glass of plain apple juice. All operations were performed by the same surgical team, under the same general anesthesia protocol. Postoperative pain was measured using the Visual Analogue Scale (VAS) at 3, 6, 12, 18, and 24 hours. For statistical analysis; the significance level was set at 0.05 using SPSS 23.</span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:150%"><span calibri=""><b><span garamond="">Results</span></b><span garamond="">: A total of 60 consecutive patients, consisting of 36 females (60%) and 24 males (40%) with an average age of 25.4 ± 6.0 were recruited. An increasing trend was noticed in the amount of perceived postoperative pain from the 3<sup>rd</sup> till 12<sup>th</sup> hour, and then decreased afterward. Nevertheless, the average amount of pain was significantly lower in the tizanidine compared to the placebo group, in all the evaluated time intervals (<i>P</i><0.001). Moreover, there was a significantly higher requirement for postoperative opioid analgesics in the placebo compared to the tizanidine group (<i>P</i>=0.011). </span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:150%"><span calibri=""><b><span garamond="">Conclusion</span></b><span garamond="">: The addition of oral tizanidine was effective in reducing postoperative pain following bimaxillary orthognathic surgery. Further studies are necessary for more relevancy.</span></span></span></span><br>
</span>
Tizanidine, Postoperative pain, Bimaxillary Orthognathic surgery
37
45
http://wjps.ir/browse.php?a_code=A-10-466-35&slc_lang=en&sid=1
Saleh
Dadmehr
100319475328460012873
100319475328460012873
No
Department of Oral and Maxillofacial Surgery, Student Research Committee, Faculty of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.
Zahra
Shooshtari
100319475328460012874
100319475328460012874
No
Student Research Committee, Faculty of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.
Mohammad
Alipour
100319475328460012875
100319475328460012875
No
Department of Anesthesiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Majid
Eshghpour
100319475328460012876
100319475328460012876
No
Department of Oral and Maxillofacial Surgery, Mashhad University of Medical Sciences, Mashhad, Iran.
Baratollah
Shaban
100319475328460012877
100319475328460012877
No
Oral and Maxillofacial Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Touraj
Vaezi
100319475328460012878
100319475328460012878
No
Department of Oral and Maxillofacial Surgery, Mashhad University of Medical Sciences, Mashhad, Iran.
Sahand
Samieirad
100319475328460012879
100319475328460012879
Yes
Dental Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.