WORLD JOURNAL OF PLASTIC SURGERY
مجله جهانی جراحی پلاستیک
WJPS
Medical Sciences
http://wjps.ir
1
admin
2228-7914
2252-0724
8
10.61186/wjps
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8888
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en
jalali
1401
5
1
gregorian
2022
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1
11
3
online
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fulltext
en
Comparison of the Effect of Injectable Tranexamic Acid and Inhaled Desmopressin in Controlling Bleeding and Ecchymosis in Open Rhinoplasty
تخصصي
Special
مقالات اصيل
Original Article
<span style="font-family:Times New Roman;"><span style="font-size:11pt"><span style="line-height:150%"><b><span style="font-size:12.0pt"><span style="line-height:150%">Background</span></span></b><span style="font-size:12.0pt"><span style="line-height:150%">: Bleeding during rhinoplasty surgery has a negative effect on the quality of surgery; so, it is important to reduce bleeding during rhinoplasty. We aimed to evaluate the effect of injectable tranexamic acid (TXA) and nasal spray of desmopressin (DDAVP) on reduction in intraoperative bleeding and ecchymosis after open rhinoplasty.</span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:150%"><b><span style="font-size:12.0pt"><span style="line-height:150%">Methods</span></span></b><span style="font-size:12.0pt"><span style="line-height:150%">: In a Randomized Clinical Trial ( RCT) prepared since 2020 to 2021 in Razi Hospital and Imam Khomeini Hospital, Tehran, Iran on 42 patients who underwent open rhinoplasty were divided into three groups. In the first group, TXA was injected one hour before surgery at a dose of 10 mg / kg with a placebo inhalation spray. In the second group, DDAVP was administered as a nasal spray at a dose of 40 mcg with a placebo injection. The third group received a placebo spray and placebo injection. All required data were gathered and analyzed.</span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:150%"><b><span style="font-size:12.0pt"><span style="line-height:150%">Results</span></span></b><span style="font-size:12.0pt"><span style="line-height:150%">: In TXA group and DDAVP groups, the volume of bleeding during surgery significantly (<i>P</i>=0.022) decreased compared to placebo group, also, the quality of the surgical field and the surgeon's satisfaction significantly (<i>P</i>=0.007) improved compared to the placebo group but not with each other. Unlike placebo group, there were no reports of postoperative bleeding in the TXA and DDAVP groups. Duration of surgery, ecchymosis on the day after surgery and coagulation tests before and after surgery were not significantly different in three groups. </span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:150%"><b><span style="font-size:12.0pt"><span style="line-height:150%">Conclusion</span></span></b><span style="font-size:12.0pt"><span style="line-height:150%">: Use of DDAVP and TXA can both reduce the amount of bleeding during surgery and postoperative bleeding in rhinoplasty and improve the quality of the surgical field and the surgeon 's satisfaction during surgery.</span></span></span></span></span><br>
Tranexamic Acid, Inhaled Desmopressin, Rhinoplasty, Ecchymosis
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http://wjps.ir/browse.php?a_code=A-10-200-9&slc_lang=en&sid=1
Shahriar Haddady
Abianeh
100319475328460013452
100319475328460013452
No
Department of Plastic and Reconstructive Surgery, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Javad
Rahmati
100319475328460013453
100319475328460013453
No
Department of Plastic and Reconstructive Surgery, Faculty of Medicine, Razi Hospital, Tehran, Iran
Changiz
Delavari
100319475328460013454
100319475328460013454
No
Department of Plastic and Reconstructive Surgery, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Hojjat
Molaei
100319475328460013455
100319475328460013455
Yes
Department of Plastic and Reconstructive Surgery, Faculty of Medicine, Sina Hospital, Tehran, Iran