مجله جهانی جراحی پلاستیک
مجله جهانی جراحی پلاستیک
یکشنبه 19 اسفند 1403
[Archive]
دوره 13، شماره 2 - ( 1403 )
جلد 13 شماره 2 صفحات 49-44 |
برگشت به فهرست نسخه ها
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Pazyar N, Sananzadeh S, yaghoobi R, Bakhtiari N. Comparison of Intralesional Vitamin D with Intralesional Triamcinolone Acetonide in the Treatment of Keloids. WJPS 2024; 13 (2) :44-49
URL: http://wjps.ir/article-1-1302-fa.html
URL: http://wjps.ir/article-1-1302-fa.html
Comparison of Intralesional Vitamin D with Intralesional Triamcinolone Acetonide in the Treatment of Keloids. مجله جهانی جراحی پلاستیک. 1403; 13 (2) :44-49
چکیده: (1572 مشاهده)
Background: Hypertrophic scars and keloids are disorders caused by the excessive growth of connective tissue, associated with the accumulation of collagen and cellular matrix components. These scars are caused by abnormal wound healing and can have a great impact on patients' lives. Therefore, we aimed to compare the effect of intralesional injection of vitamin D with triamcinolone acetonide in the treatment of keloid.
Methods: This study was a one-sided blind clinical trial, conducted on 22 patients (44 samples) with keloid. It was a randomized, blinded clinical trial, conducted in Imam Khomeini Hospital in Ahvaz, Iran in 2022. In each group, triamcinolone or vitamin D was injected at the lesion site with an interval of three weeks and an average of 6 sessions. The patients were re-evaluated 3 months after the end of the treatment in terms of recurrence.
Results: By examining the VSS scale in each of the groups, this scale decreased significantly in both groups after the intervention (P=0.001), which was greater in the group receiving triamcinolone (P=0.001).
Conclusion: It seems that the injection of vitamin D at the site of the lesion helps to treat it, but the effectiveness of the usual triamcinolone treatment was still higher, it is suggested to use vitamin D as an adjunctive treatment in these patients.
Methods: This study was a one-sided blind clinical trial, conducted on 22 patients (44 samples) with keloid. It was a randomized, blinded clinical trial, conducted in Imam Khomeini Hospital in Ahvaz, Iran in 2022. In each group, triamcinolone or vitamin D was injected at the lesion site with an interval of three weeks and an average of 6 sessions. The patients were re-evaluated 3 months after the end of the treatment in terms of recurrence.
Results: By examining the VSS scale in each of the groups, this scale decreased significantly in both groups after the intervention (P=0.001), which was greater in the group receiving triamcinolone (P=0.001).
Conclusion: It seems that the injection of vitamin D at the site of the lesion helps to treat it, but the effectiveness of the usual triamcinolone treatment was still higher, it is suggested to use vitamin D as an adjunctive treatment in these patients.
فهرست منابع
1. Naeini FF, Najafian J, Ahmadpour K. Bleomycin tattooing as a promising therapeutic modality in large keloids and hypertrophic scars. Dermatol Surg 2006;32(8):1023-30. [DOI:10.1111/j.1524-4725.2006.32225.x]
3. Shaldoum DR, Hassan GF, El Maadawy EH, El‐Maghraby GM. Comparative clinical study of the efficacy of intralesional MMR vaccine vs intralesional vitamin D injection in treatment of warts. J Cosmet Dermatol 2020;19(8):2033-40. [DOI:10.1111/jocd.13272]
5. El Sayed MH, Sayed FS, Afify AA. Intralesional zinc sulfate 2% vs intralesional vitamin D in plantar warts: A clinicodermoscopic study. Dermatol Ther 2020;33(3):e13308. [DOI:10.1111/dth.13308]
7. Kelemen O, Kollár L. Current methods of treatment and prevention of pathologic scars. Magy Seb 2007;60(2):63-70. [DOI:10.1556/maseb.60.2007.2.1]
9. Ledon JA, Savas J, Franca K, Chacon A, Nouri K. Intralesional treatment for keloids and hypertrophic scars: a review. Dermatol Surg 2013;39(12):1745-57. [DOI:10.1111/dsu.12346]
11. Draaijers LJ, Tempelman FR, Botman YA, Tuinebreijer WE, Middelkoop E, Kreis RW, et al. The patient and observer scar assessment scale: a reliable and feasible tool for scar evaluation. Plast Reconst Surg 2004;113(7):1960-5. [DOI:10.1097/01.PRS.0000122207.28773.56]
13. Gauglitz GG, Korting HC, Pavicic T, Ruzicka T, Jeschke MG. Hypertrophic scarring and keloids: pathomechanisms and current and emerging treatment strategies. Mol Med 2011;17(1):113-25. [DOI:10.2119/molmed.2009.00153]
15. Shaffer JJ, Taylor SC, Cook-Bolden F. Keloidal scars: a review with a critical look at therapeutic options. JAAD 2002;46(2):S63-S97. [DOI:10.1067/mjd.2002.120788]
17. Saray Y, Güleç AT. Treatment of keloids and hypertrophic scars with dermojet injections of bleomycin: a preliminary study. Int J Dermatol 2005;44(9):777-84. [DOI:10.1111/j.1365-4632.2005.02633.x]
19. Wang R, Mao Y, Zhang Z, Li Z, Chen J, Cen Y. Role of verapamil in preventing and treating hypertrophic scars and keloids. Int Wound J 2016;13(4):461-8. [DOI:10.1111/iwj.12455]
21. Zhang GY, Cheng T, Luan Q, Liao T, Nie CL, Zheng X, et al. Vitamin D: a novel therapeutic approach for keloid, an in vitro analysis. Br J Dermatol 2011; 164:729-37. [DOI:10.1111/j.1365-2133.2010.10130.x]
23. Ramirez AM, Wongtrakool C, Welch T, Steinmeyer A, Zügel U, Roman J. Vitamin D inhibition of pro-fibrotic effects of transforming growth factor β1 in lung fibroblasts and epithelial cells. JSBBEZ 2010;118(3):142-50. [DOI:10.1016/j.jsbmb.2009.11.004]
25. Damanik VI, Putra IB, Ginting O. Correlation between serum 25-hydroxyvitamin D levels with keloid severity. Maced J Med Sci 2019;7(1):65. [DOI:10.3889/oamjms.2019.022]
27. Mamdouh M, Omar GA, Hafiz HS, Ali SM. Role of vitamin D in treatment of keloid. J Cosmet Dermatol 2022;21(1):331-6. [DOI:10.1111/jocd.14070]
29. Ahuja RB, Chatterjee P. Comparative efficacy of intralesional verapamil hydrochloride and triamcinolone acetonide in hypertrophic scars and keloids. Burns 2014;40(4):583-8. [DOI:10.1016/j.burns.2013.09.029]
| بازنشر اطلاعات | |
 |
این مقاله تحت شرایط Creative Commons Attribution-NonCommercial 4.0 International License قابل بازنشر است. |
