WORLD JOURNAL OF PLASTIC SURGERY
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Volume 13, Issue 1 (2024)
WJPS 2024, 13(1): 24-31 |
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Mamizadeh M, Ghorabi S T, Mansourinia Z, Shadfar F, Rouzbahani A K. Comparison the Effect of Conventional and Nanofat Injection Methods on Nasolabial Fold Lipofilling: A Case- Control Study. WJPS 2024; 13 (1) :24-31
URL: http://wjps.ir/article-1-1222-en.html
URL: http://wjps.ir/article-1-1222-en.html
Mina Mamizadeh1 
, Samaneh Tahmasebi Ghorabi2 , Zahra Mansourinia3 , Fariba Shadfar1 , Arian Karimi Rouzbahani 4
, Samaneh Tahmasebi Ghorabi2 , Zahra Mansourinia3 , Fariba Shadfar1 , Arian Karimi Rouzbahani 4
1- Department of Dermatology, School of Medicine, Emam Khomeini Hospital, Ilam University of Medical sciences, Ilam, Iran
2- USERN Office, Lorestan University of Medical Sciences, Khorramabad, Iran
3- Ilam University of Medical Sciences, Ilam, Iran
4- USERN Office, Lorestan University of Medical Sciences, Khorramabad, Iran , ariankarimi1998@gmail.com
2- USERN Office, Lorestan University of Medical Sciences, Khorramabad, Iran
3- Ilam University of Medical Sciences, Ilam, Iran
4- USERN Office, Lorestan University of Medical Sciences, Khorramabad, Iran , ariankarimi1998@gmail.com
Abstract: (505 Views)
ABSTRACT
Background: Nasolabial folds are a common sign of aging, accompanied by various manifestations such as skin and tissue loosening, wrinkles, lip corner drooping, mandibular angle loss, platysmal bands, and skin pigmentation changes. Limited research has explored Nanofat injection methods. this study was done with the aim of comparing the effect of fat injection by two methods, conventional and Nanofat, in nasolabial folds.
Method: The study conducted in 2020-2021 at the skin clinic in Ilam, western Iran was a case-control study. Participants were divided into two groups, and lipofilling procedures were performed using conventional and nanofat methods with autologous fat. Data collection utilized a researcher-made questionnaire and radiographic results. Follow-up visits occurred on the 30th, 90th, and 180th days to assess complications and recovery rates. After 6 months, participant's photographs were taken and compared with pre-intervention photographs using the GIAS criteria. Data analysis was conducted using SPSS22 version software.
Results: The average age of the participants was 37.80±8.30 yr. The treatment response in the conventional fat injection group was significantly better than the nanofat group (P<0.05). Both groups were satisfied with the treatment methods, but high satisfaction was reported in the conventional group, but there was no statistically significant difference between the groups.
Conclusion: Both methods of improving wrinkles were effective, but the improvement and response to treatment in the conventional method was better than the Nanofat method, and its effect was felt by the participants for an average period of 3 months.
Background: Nasolabial folds are a common sign of aging, accompanied by various manifestations such as skin and tissue loosening, wrinkles, lip corner drooping, mandibular angle loss, platysmal bands, and skin pigmentation changes. Limited research has explored Nanofat injection methods. this study was done with the aim of comparing the effect of fat injection by two methods, conventional and Nanofat, in nasolabial folds.
Method: The study conducted in 2020-2021 at the skin clinic in Ilam, western Iran was a case-control study. Participants were divided into two groups, and lipofilling procedures were performed using conventional and nanofat methods with autologous fat. Data collection utilized a researcher-made questionnaire and radiographic results. Follow-up visits occurred on the 30th, 90th, and 180th days to assess complications and recovery rates. After 6 months, participant's photographs were taken and compared with pre-intervention photographs using the GIAS criteria. Data analysis was conducted using SPSS22 version software.
Results: The average age of the participants was 37.80±8.30 yr. The treatment response in the conventional fat injection group was significantly better than the nanofat group (P<0.05). Both groups were satisfied with the treatment methods, but high satisfaction was reported in the conventional group, but there was no statistically significant difference between the groups.
Conclusion: Both methods of improving wrinkles were effective, but the improvement and response to treatment in the conventional method was better than the Nanofat method, and its effect was felt by the participants for an average period of 3 months.
References
1. Maranduca MA, Branisteanu D, Serban DN, et al. Synthesis and physiological implications of melanic pigments. Oncol Lett 2019;17(5):4183-7. [DOI:10.3892/ol.2019.10071]
2. Someya T, Amagai M. Toward a new generation of smart skins. Nat Biotechnol 2019;37(4):382-8. [DOI:10.1038/s41587-019-0079-1]
3. Yousef H, Alhajj M, Sharma S. Anatomy, skin (integument), epidermis. 2017.
4. Lyu J-J, Liu S-X. Radiofrequency in facial rejuvenation. International Journal of Dermatology and Venereology 2022;5(02):94-100. [DOI:10.1097/JD9.0000000000000193]
5. Han A, Chien AL, Kang S. Photoaging. Dermatol Clin 2014;32(3):291-9. [DOI:10.1016/j.det.2014.03.015]
6. Stefura T, Kacprzyk A, Droś J, et al. Tissue Fillers for the Nasolabial Fold Area: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. Aesthetic Plast Surg 2021 2021/10/01;45(5):2300-16. [DOI:10.1007/s00266-021-02439-5]
7. Ganceviciene R, Liakou AI, Theodoridis A, Makrantonaki E, Zouboulis CC. Skin anti-aging strategies. Dermatoendocrinol 2012;4(3):308-19. [DOI:10.4161/derm.22804]
8. Arsiwala SZ. Current trends in facial rejuvenation with fillers. J Cutan Aesthet Surg 2015;8(3):125-6. [DOI:10.4103/0974-2077.167261]
9. Campa M, Baron E. Anti-aging effects of select botanicals: Scientific evidence and current trends. Cosmetics 2018;5(3):1-15. [DOI:10.3390/cosmetics5030054]
10. Tonnard P, Verpaele A, Peeters G, Hamdi M, Cornelissen M, Declercq H. Nanofat grafting: basic research and clinical applications. Plast Reconstr Surg 2013;132(4):1017-26. [DOI:10.1097/PRS.0b013e31829fe1b0]
11. van Dongen JA, Langeveld M, van de Lande LS, Harmsen MC, Stevens HP, van der Lei B. The effects of facial lipografting on skin quality: a systematic review. Plast Reconstr Surg 2019;144(5):784e-97e. [DOI:10.1097/PRS.0000000000006147]
12. van Dongen JA, Boxtel JV, Willemsen JC, et al. The Addition of Tissue Stromal Vascular Fraction to Platelet-Rich Plasma Supplemented Lipofilling Does Not Improve Facial Skin Quality: A Prospective Randomized Clinical Trial. Aesthet Surg J 2021;41(8):NP1000-NP13. [DOI:10.1093/asj/sjab109]
13. Spiekman M, van Dongen JA, Willemsen JC, Hoppe DL, van der Lei B, Harmsen MC. The power of fat and its adipose‐derived stromal cells: emerging concepts for fibrotic scar treatment. J Tissue Eng Regen Med 2017;11(11):3220-35. [DOI:10.1002/term.2213]
14. Charles-de-Sá L, Gontijo-de-Amorim NF, Takiya CM, et al. Antiaging treatment of the facial skin by fat graft and adipose-derived stem cells. Plast Reconstr Surg 2015;135(4):999-1009. [DOI:10.1097/PRS.0000000000001123]
15. Guisantes E, Fontdevila J, Rodríguez G. Autologous fat grafting for correction of unaesthetic scars. Ann Plast Surg 2012;69(5):550-4. [DOI:10.1097/SAP.0b013e31821ee386]
16. Uyulmaz S, Sanchez Macedo N, Rezaeian F, Giovanoli P, Lindenblatt N. Nanofat Grafting for Scar Treatment and Skin Quality Improvement. Aesthet Surg J 2018;38(4):421-8. [DOI:10.1093/asj/sjx183]
17. Bernardini FP, Skippen B, Gennai A, Zambelli A. Minimal Incisions Vertical Endoscopic Lifting (MIVEL) for the management of lateral canthal and lower eyelid malposition. Aesthet Surg J 2019;39(5):472-80. [DOI:10.1093/asj/sjy244]
18. Monheit G, Beer K, Hardas B, Grimes PE, Weichman BM, Lin V, Murphy DK. Safety and Effectiveness of the Hyaluronic Acid Dermal Filler VYC-17.5L for Nasolabial Folds: Results of a Randomized, Controlled Study. Dermatol Surg 2018;44(5):670-678. [DOI:10.1097/DSS.0000000000001529]
19. La Padula S, Ponzo M, Lombardi M, et al. Nanofat in Plastic Reconstructive, Regenerative, and Aesthetic Surgery: A Review of Advancements in Face-Focused Applications. J Clin Med 2023;12(13):1-19. [DOI:10.3390/jcm12134351]
20. Fakih-Gomez N, Steward E, Orte Aldea M del C. Nanofat in Facial Rejuvenation: Step-by-Step Procedure, Patient Evaluation and Recovery Process. The American Journal of Cosmetic Surgery 2021;38(1):27-35. [DOI:10.1177/0748806820919935]
21. Ehlinger-David A, Gorj M, Braccini F, Loreto F, et al. A prospective multicenter clinical trial evaluating the efficacy and safety of a hyaluronic acid-based filler with Tri-Hyal technology in the treatment of lips and the perioral area. J Cosmet Dermatol 2023;22(2):464-472. [DOI:10.1111/jocd.15169]
22. Erol OO, Agaoglu G. Facial rejuvenation with staged injections of cryopreserved fat and tissue cocktail: clinical outcomes in the past 10 years. Aesthet Surg J 2013;33(5):639-53. [DOI:10.1177/1090820X13493904]
23. Chou C, Lee S, Lin T, et al. Micro-autologous fat transplantation (MAFT) for forehead volumizing and contouring. Aesthetic Plast Surg 2017;41:845-55. [DOI:10.1007/s00266-017-0883-2]
24. Coleman SR, Katzel EB. Fat grafting for facial filling and regeneration. Clin Plast Surg 2015;42(3):289-300. [DOI:10.1016/j.cps.2015.04.001]
25. Sinno S, Wilson S, Brownstone N, Levine SM. Current thoughts on fat grafting: using the evidence to determine fact or fiction. Plast Reconstr Surg 2016;137(3):818-24. [DOI:10.1097/01.prs.0000479966.52477.8b]
26. Klar AS, Güven S, Zimoch J, et al. Characterization of vasculogenic potential of human adipose-derived endothelial cells in a three-dimensional vascularized skin substitute. Pediatr Surg Int 2016;32:17-27. [DOI:10.1007/s00383-015-3808-7]
27. Moon KM, Park Y-H, Lee JS, et al. The effect of secretory factors of adipose-derived stem cells on human keratinocytes. International journal of molecular sciences 2012;13(1):1239-57. [DOI:10.3390/ijms13011239]
28. Jacovella PF. Use of calcium hydroxylapatite (Radiesse®) for facial augmentation. Clin Interv Aging 2008;3(1):161-74. [DOI:10.2147/CIA.S2065]
29. Zzam E, Khlosy H, Abouarab M. The Efficacy of Autologous Nanofat Injection in the Treatment of Infraorbital Dark Colouration. The Egyptian Journal of Plastic and Reconstructive Surgery 2020; 43(3): 445-452. doi: 10.21608/ejprs.2020.68188. [DOI:10.21608/ejprs.2020.68188]
30. Vavouli C, Katsambas A, Gregoriou S, et al. Chemical peeling with trichloroacetic acid and lactic acid for infraorbital dark circles. J Cosmet Dermatol 2013;12(3):204-9. [DOI:10.1111/jocd.12044]
31. Baumann LS, Shamban AT, Lupo MP, et al. Comparison of smooth‐gel hyaluronic acid dermal fillers with cross‐linked bovine collagen: a multicenter, double‐masked, randomized, within‐subject study. Dermatol Surg 2007;33:S128-S35. [DOI:10.1097/00042728-200712001-00004]
32. Menkes S, Luca M, Soldati G, Polla L. Subcutaneous injections of nanofat adipose-derived stem cell grafting in facial rejuvenation. Plastic and reconstructive surgery Global open 2020;8(1):1-9. [DOI:10.1097/GOX.0000000000002550]
33. Tonnard P, Verpaele A, Carvas M. Fat grafting for facial rejuvenation with nanofat grafts. Clin Plast Surg 2020;47(1):53-62. [DOI:10.1016/j.cps.2019.08.006]
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