WORLD JOURNAL OF PLASTIC SURGERY
Thu, Apr 25, 2024
[Archive]
Volume 8, Issue 1 (2019)
WJPS 2019, 8(1): 58-61 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Hassanpour S E, Rostami K, Azargashb E, Saberi K, Hamraz S H, Farajzadeh Vajari F et al . The Effect of Topical Vitamin A and E on Ischemic Random Skin Flap Survival. WJPS 2019; 8 (1) :58-61
URL: http://wjps.ir/article-1-408-en.html
URL: http://wjps.ir/article-1-408-en.html
Seyed Esmail Hassanpour1 
, Khalil Rostami2 , Eznollah Azargashb3 , Kourosh Saberi4 , Seyyed Hosein Hamraz5 , Fatemeh Farajzadeh Vajari6 , Hojjat Molaei 7
, Khalil Rostami2 , Eznollah Azargashb3 , Kourosh Saberi4 , Seyyed Hosein Hamraz5 , Fatemeh Farajzadeh Vajari6 , Hojjat Molaei 7
1- professor of plastic &reconstructive surgery, medicine school, TShahid Beheshti University of Medical Sciences, Tehran, Iran
2- assistant professor of plastic &reconstructive surgery, medicine school, TShahid Beheshti University of Medical Sciences, Tehran, Iran
3- Assistant Professor of Departmen of community medicine,School of medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4- Assistant Professor of plastic & reconstructive surgery .Semnan University of Medical Sciences, Semnan, Iran
5- Aassistant professor of plastic &reconstructive sushahid Beheshti University of Medical Sciences, Tehran, Iran
6- Gynecologist surgeon, Privat practice , Tehran, Iran
7- Aassistant professor of plastic &reconstructive surgery, medicine school, Tehran University of Medical Sciences, Tehran, Iran , hmggprs@gmail.com
2- assistant professor of plastic &reconstructive surgery, medicine school, TShahid Beheshti University of Medical Sciences, Tehran, Iran
3- Assistant Professor of Departmen of community medicine,School of medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4- Assistant Professor of plastic & reconstructive surgery .Semnan University of Medical Sciences, Semnan, Iran
5- Aassistant professor of plastic &reconstructive sushahid Beheshti University of Medical Sciences, Tehran, Iran
6- Gynecologist surgeon, Privat practice , Tehran, Iran
7- Aassistant professor of plastic &reconstructive surgery, medicine school, Tehran University of Medical Sciences, Tehran, Iran , hmggprs@gmail.com
Abstract: (4435 Views)
BACKGROUND
Ischemia of skin flaps is an important complication in reconstructive surgery. This study evaluated the efficacy of topical vitamins A and E on improving flap survival.
METHODS
Twenty-four white-albino male rats were randomly divided into two groups of treatment and control. Standard rectangular, distally based dorsal random pattern skin flap was elevated. Intra-peritoneal cephazoline was administered to prevent any unexpected infection. No pharmaceutical agent was administered for the control group, but pure vaseline ointment. In treatment group, vaseline plus vitamins A and E were administrated daily after surgery for 10 days. The rats were evaluated on the 10th day after surgery for viable and necrotic portions of the flaps.
RESULTS
The mean values of necrosis in the flaps were 625±189.56 and 920.00±247.31 in the treatment and control groups, respectively. Vaseline plus vitamins increased flap survival significantly. CONCLUSION
Topical vitamins A and E may be effective pharmaceutical agents to increase viability of random skin flaps in rats. They can be added to vasoactive topical agents to reach better results.
Ischemia of skin flaps is an important complication in reconstructive surgery. This study evaluated the efficacy of topical vitamins A and E on improving flap survival.
METHODS
Twenty-four white-albino male rats were randomly divided into two groups of treatment and control. Standard rectangular, distally based dorsal random pattern skin flap was elevated. Intra-peritoneal cephazoline was administered to prevent any unexpected infection. No pharmaceutical agent was administered for the control group, but pure vaseline ointment. In treatment group, vaseline plus vitamins A and E were administrated daily after surgery for 10 days. The rats were evaluated on the 10th day after surgery for viable and necrotic portions of the flaps.
RESULTS
The mean values of necrosis in the flaps were 625±189.56 and 920.00±247.31 in the treatment and control groups, respectively. Vaseline plus vitamins increased flap survival significantly. CONCLUSION
Topical vitamins A and E may be effective pharmaceutical agents to increase viability of random skin flaps in rats. They can be added to vasoactive topical agents to reach better results.
References
1. Browne EZ, Jr. Complications of skin grafts and pedicle flaps. Hand Clin 1986;2:353-9.
2. Chung KI, Kim HK, Kim WS, Bae TH. The effects of polydeoxyribonucleotide on the survival of random pattern skin flaps in rats. Arch Plast Surg 2013;40:181-6. doi: 10.5999/aps.2013.40.3.181. [DOI:10.5999/aps.2013.40.3.181]
3. Smith DK, Dolan RW. Effects of vasoactive topical agents on the survival of dorsal skin flaps in rats. Otolaryngol Head Neck Surg 1999;121:220-3. doi: 10.1016/S0194-5998(99)70175-0. [DOI:10.1016/S0194-5998(99)70175-0]
4. McFarlane RM, Deyoung G, Henry RA. The Design of a Pedicle Flap in the Rat to Study Necrosis and Its Prevention. Plast Reconstr Surg 1965;35:177-82. doi: 10.1097/00006534-196502000-00007. [DOI:10.1097/00006534-196502000-00007]
5. Harder Y, Amon M, Laschke MW, Schramm R, Rucker M, Wettstein R, Bastiaanse J, Frick A, Machens HG, Kuntscher M, Germann G, Vollmar B, Erni D, Menger MD. An old dream revitalised: preconditioning strategies to protect surgical flaps from critical ischaemia and ischaemia-reperfusion injury. J Plast Reconstr Aesthet Surg 2008;61:503-11. doi: 10.1016/j.bjps.2007.11.032. [DOI:10.1016/j.bjps.2007.11.032]
6. Machado AF, Santana EF, Tacani PM, Liebano RE. The effects of transcutaneous electrical nerve stimulation on tissue repair: A literature review. Can J Plast Surg 2012;20:237-40. doi: 10.4172/plastic-surgery.1000786. [DOI:10.4172/plastic-surgery.1000786]
7. Bilgen K, Bilgen E, Cetinkunar S, Celep RB, Isik S. The efficacy of topical phenytoin and capsaicin on random pattern dorsal skin flaps in rats. Ann Ital Chir 2017;88:87-93.
8. Kjartansson J, Dalsgaard CJ, Jonsson CE. Decreased survival of experimental critical flaps in rats after sensory denervation with capsaicin. Plast Reconstr Surg 1987;79:218-21. doi: 10.1097/00006534-198702000-00012. [DOI:10.1097/00006534-198702000-00012]
9. Komurcu E, Ozkan OF, Kemik AS, Nusran G, Asik M, Arslan E. Effect of systemic carnitine therapy on serum fibronectin level in diabetic rats. J Surg Res 2014;187:712-7. doi: 10.1016/j.jss.2013.11.1101. [DOI:10.1016/j.jss.2013.11.1101]
10. Lawanlakkana P, Saraithong S, Suwantemee C, Pitiseree A. Comparing the effect between oral and injection form of carnitine on skin flap survival in rats. J Med Assoc Thai 2012;95 Suppl 5:S157-61.
11. Georgopoulos S, Mastorakos D, Kondi-Pafiti A, Katsenis K, Arkadopoulos N, Kannas D, Archontaki M, Vestarchis N, Kokkalis G. Hydroxyzine, cimetidine and vitamin C in reducing skin flap necrosis in ischemia-reperfusion injury in rats. A comparative study. J BUON 2012;17:377-82.
12. Kwon ST, Jeong JH, Eun SC, Baek RM, Minn KW, Heo CY. The effects of mega-dose ascorbic acid on skin flap survival: experimental study on rats. J Plast Reconstr Aesthet Surg 2009;62:e641-2. doi: 10.1016/j.bjps.2008.11.094. [DOI:10.1016/j.bjps.2008.11.094]
13. Hayden RE, Paniello RC, Yeung CS, Bello SL, Dawson SM. The effect of glutathione and vitamins A, C, and E on acute skin flap survival. Laryngoscope 1987;97:1176-9. doi: 10.1288/00005537-198710000-00011. [DOI:10.1288/00005537-198710000-00011]
14. Bilgin-Karabulut A, Ademoglu E, Aydin I, Erer M, Gokkusu C. Protective effects of vitamins A and E pretreatment in venous ischemia/reperfusion injury. J Reconstr Microsurg 2001;17:425-9. doi: 10.1055/s-2001-16356. [DOI:10.1055/s-2001-16356]
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
