WORLD JOURNAL OF PLASTIC SURGERY
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Volume 10, Issue 1 (2021)
WJPS 2021, 10(1): 53-59 |
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Jaafari-Sheybani F, Hosseini S, Mehrabani D, Derakhshanfar A, Karimi-Busheri F. Histological Changes in Adipose Tissue: An Alarm When Methamphetamine Is Targeted for Weight Loss Purposes. WJPS 2021; 10 (1) :53-59
URL: http://wjps.ir/article-1-611-en.html
URL: http://wjps.ir/article-1-611-en.html
Fariba Jaafari-Sheybani1 
, Seyed-Ebrahim Hosseini * 2, Davood Mehrabani3 , Amin Derakhshanfar4 , Feridoun Karimi-Busheri5
, Seyed-Ebrahim Hosseini * 2, Davood Mehrabani3 , Amin Derakhshanfar4 , Feridoun Karimi-Busheri5
1- Department of Biology, Shiraz Branch, Islamic Azad University, Shiraz, Iran
2- Department of Biology, Shiraz Branch, Islamic Azad University, Shiraz, Iran ,ebrahim.hossini@yahoo.com
3- Stem Cell Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
4- Diagnostic Laboratory Sciences and Technology Research Center, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
5- Department of Oncology, University of Alberta, Edmonton, Alberta, Canada
2- Department of Biology, Shiraz Branch, Islamic Azad University, Shiraz, Iran ,
3- Stem Cell Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
4- Diagnostic Laboratory Sciences and Technology Research Center, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
5- Department of Oncology, University of Alberta, Edmonton, Alberta, Canada
Abstract: (4714 Views)
BACKGROUND
Methamphetamine (METH) may be administered for weight loss purposes and to understand the METH side-effects more in details, this study aimed at determining the effect of METH on changes in adipose tissue in experimental rats.
METHODS
Forty five male Wistar rats were randomly allocated to three equal groups. Group 1 was experimental receiving METH [0.4 mg/kg, subcutaneously (S/C), 0.6 mL/rat] for 3 weeks, group 2 was the sham group receiving normal saline (0.6 mL/rat, S/C) and the 3rd group was the control receiving distilled water, identically. The elevated plus maze test was used to confirm cognitive impairment and distraction as anxiety and to verify addiction to METH by assessing the percent time spent in open arm (OAT), the percent time spent in closed arm (CAT), the percent time spent in central parts and head dipping over the side of the maze. Adipose tissue was assessed histologically 7, 14 and 21-days after interventions.
RESULTS
A significant increase in anxiety level, and histologically inflammation, degeneration and necrosis in adipose tissue were visible after METH use.
CONCLUSION
METH use resulted in a significant inflammation and necrosis in adipose tissue denoting to the dangers of METH use, when recreationally targeted for weight loss purposes.
Methamphetamine (METH) may be administered for weight loss purposes and to understand the METH side-effects more in details, this study aimed at determining the effect of METH on changes in adipose tissue in experimental rats.
METHODS
Forty five male Wistar rats were randomly allocated to three equal groups. Group 1 was experimental receiving METH [0.4 mg/kg, subcutaneously (S/C), 0.6 mL/rat] for 3 weeks, group 2 was the sham group receiving normal saline (0.6 mL/rat, S/C) and the 3rd group was the control receiving distilled water, identically. The elevated plus maze test was used to confirm cognitive impairment and distraction as anxiety and to verify addiction to METH by assessing the percent time spent in open arm (OAT), the percent time spent in closed arm (CAT), the percent time spent in central parts and head dipping over the side of the maze. Adipose tissue was assessed histologically 7, 14 and 21-days after interventions.
RESULTS
A significant increase in anxiety level, and histologically inflammation, degeneration and necrosis in adipose tissue were visible after METH use.
CONCLUSION
METH use resulted in a significant inflammation and necrosis in adipose tissue denoting to the dangers of METH use, when recreationally targeted for weight loss purposes.
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