مجله جهانی جراحی پلاستیک
مجله جهانی جراحی پلاستیک
پنجشنبه 1 آذر 1403
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دوره 11، شماره 1 - ( 1400 )
جلد 11 شماره 1 صفحات 37-30 |
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Iranpour M, Khodarahmi A, Beigi M, Azari O, Shahraki S S. Effects of Botulinum Toxin Type A on the Axial Skin Flap Survival. WJPS 2022; 11 (1) :30-37
URL: http://wjps.ir/article-1-898-fa.html
URL: http://wjps.ir/article-1-898-fa.html
Effects of Botulinum Toxin Type A on the Axial Skin Flap Survival. مجله جهانی جراحی پلاستیک. 1400; 11 (1) :30-37
چکیده: (2308 مشاهده)
BACKGROUND
A suitable pharmacological substitute for the well-established surgical delay technique for axial skin flaps regarding increasing viability is elusive. We aimed to evaluate the effects of botulinum toxin type A (BTA) on the axial skin flap survival in a rat model.
METHODS
The present controlled experimental study was performed in Kerman University of Medical Science, Kermanshah, Iran during 2016-2017 on three groups of rats. Group 1 (control group) had no preconditioning while Groups 2 and 3 were preconditioned by the intradermal injection of normal saline (0.5 ml) in the cephalic end of the skin flap and the injection of the BTA (1.6 units Neuronex) reconstituted in normal saline, respectively. Two weeks after this intervention in each group, the flap was raised and kept in situ and a biopsy was simultaneously taken for evaluating neoangiogenesis, followed by evaluating flap necrosis after two weeks of following-up by photography.
RESULTS
Although BTA induced angiogenesis significantly, it failed to reduce the area of necrosis compared to the other groups.
CONCLUSION
BTA was effective in increasing angiogenesis in the axial skin flap although it was unable to reduce necrosis.
A suitable pharmacological substitute for the well-established surgical delay technique for axial skin flaps regarding increasing viability is elusive. We aimed to evaluate the effects of botulinum toxin type A (BTA) on the axial skin flap survival in a rat model.
METHODS
The present controlled experimental study was performed in Kerman University of Medical Science, Kermanshah, Iran during 2016-2017 on three groups of rats. Group 1 (control group) had no preconditioning while Groups 2 and 3 were preconditioned by the intradermal injection of normal saline (0.5 ml) in the cephalic end of the skin flap and the injection of the BTA (1.6 units Neuronex) reconstituted in normal saline, respectively. Two weeks after this intervention in each group, the flap was raised and kept in situ and a biopsy was simultaneously taken for evaluating neoangiogenesis, followed by evaluating flap necrosis after two weeks of following-up by photography.
RESULTS
Although BTA induced angiogenesis significantly, it failed to reduce the area of necrosis compared to the other groups.
CONCLUSION
BTA was effective in increasing angiogenesis in the axial skin flap although it was unable to reduce necrosis.
فهرست منابع
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