WORLD JOURNAL OF PLASTIC SURGERY
Sun, Sep 22, 2024
[Archive]
Volume 11, Issue 3 (2022)
WJPS 2022, 11(3): 55-62 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Namazi P, Fatemi M J, pahlevanpour P, Abbastabar H, Naderi Gharahgheshlagh S. Comparative Effects of Recove® and Nitrofurazone 0.2% on the Treatment of First and Second-Degree Burns: a Double-Blind Randomized Clinical Trial. WJPS 2022; 11 (3) :55-62
URL: http://wjps.ir/article-1-989-en.html
URL: http://wjps.ir/article-1-989-en.html
Parviz Namazi * 
1, Mohammad Javad Fatemi1 , Parisa Pahlevanpour1 , Hedayat Abbastabar2 , Soheila Naderi Gharahgheshlagh1
1, Mohammad Javad Fatemi1 , Parisa Pahlevanpour1 , Hedayat Abbastabar2 , Soheila Naderi Gharahgheshlagh1
1- Burn Research Center, Iran University of Medical Sciences, Tehran, Iran.
2- Advance Diagnostic Interventional Radiology Research Center, Tehran University of Medical Science, Tehran, Iran
2- Advance Diagnostic Interventional Radiology Research Center, Tehran University of Medical Science, Tehran, Iran
Abstract: (1092 Views)
Background: Burns are among the major health challenges of all societies and more than any other trauma incur physical, mental, social, and economic burdens on the patient and society. This study was conducted to assess whether Recove® burn ointment is capable of alleviating the pain, preventing the formation of new blisters and controlling the microbial contamination of the wound.
Methods: We, therefore, compared its efficacy to nitrofurazone 0.2% cream. This randomized clinical trial was conducted on individuals who had two burn injuries in their body at the same time in the Motahari Burn Hospital, Tehran Province, from June to October 2016. Sampling was carried out with a non-random method using available samples. The intervention in experimental and control groups was Recove® and nitrofurazone, respectively. The effect of interventions on pain relief, the formation of new blisters and prevention of infection at the burn wound were evaluated. In our double-blind study, blindness was applied to the patients and the person evaluating the outcomes.
Results: Both Recove® and nitrofurazone interventions significantly alleviated pain (P < 0.01), but Recove ®showed more effectiveness (P=0.01). Similarly, in terms of new blister formation, the experimental group receiving Recove® showed less new blister formation over 24 hours after treatment compared to nitrofurazone group (P=0.03) and with respect to antimicrobial activity, there was no significant difference between Recove® and nitrofurazone (P=0.12).
Conclusion: Recove® was effective on pain reduction, prevention of new blisters formation as well as infection. Therefore, it seems that Recove® could be considered as a new and efficient treatment for burn.
Methods: We, therefore, compared its efficacy to nitrofurazone 0.2% cream. This randomized clinical trial was conducted on individuals who had two burn injuries in their body at the same time in the Motahari Burn Hospital, Tehran Province, from June to October 2016. Sampling was carried out with a non-random method using available samples. The intervention in experimental and control groups was Recove® and nitrofurazone, respectively. The effect of interventions on pain relief, the formation of new blisters and prevention of infection at the burn wound were evaluated. In our double-blind study, blindness was applied to the patients and the person evaluating the outcomes.
Results: Both Recove® and nitrofurazone interventions significantly alleviated pain (P < 0.01), but Recove ®showed more effectiveness (P=0.01). Similarly, in terms of new blister formation, the experimental group receiving Recove® showed less new blister formation over 24 hours after treatment compared to nitrofurazone group (P=0.03) and with respect to antimicrobial activity, there was no significant difference between Recove® and nitrofurazone (P=0.12).
Conclusion: Recove® was effective on pain reduction, prevention of new blisters formation as well as infection. Therefore, it seems that Recove® could be considered as a new and efficient treatment for burn.
References
1. Forjuoh SN. Burns in low- and middle-income countries: a review of available literature on descriptive epidemiology, risk factors, treatment, and prevention. Burns 2006 Aug;32(5):529-37. [DOI:10.1016/j.burns.2006.04.002]
2. Ye H, De S. Thermal injury of skin and subcutaneous tissues: A review of experimental approaches and numerical models. Burns 2017;43(5):909-32. [DOI:10.1016/j.burns.2016.11.014]
3. Dai T, Huang YY, Sharma SK, Hashmi JT, Kurup DB, Hamblin MR. Topical antimicrobials for burn wound infections. Recent Pat Antiinfect Drug Discov 2010 Jun 1;5(2):124-51. [DOI:10.2174/157489110791233522]
4. Yasti AC, Senel E, Saydam M, Ozok G, Coruh A, Yorganci K. Guideline and treatment algorithm for burn injuries. Ulus Travma Acil Cerrahi Derg 2015 Mar;21(2):79-89. [DOI:10.5505/tjtes.2015.88261]
5. World Health Organization. Burns. 2018 [cited 2019 December fourth]; Available from: http://www.who.int/news-room/fact-sheets/detail/burns
6. Church D, Elsayed S, Reid O, Winston B, Lindsay R. Burn wound infections. Clin Microbiol Rev 2006;19(2):403-34. [DOI:10.1128/CMR.19.2.403-434.2006]
7. Stavrou D, Weissman O, Tessone A, et al. Health related quality of life in burn patients - A review of the literature. Burns 2014 01/13;40(5):788-96. [DOI:10.1016/j.burns.2013.11.014]
8. Iran Burn statistics. 2012 [cited 2019 December fourth]; Available from: http://burnres.sums.ac.ir/medical-care-guide/burn-statistics.html
9. Ghaffari A, Manafi A, Moghimi HR. Enhancement effect of trypsin on permeation of clindamycin phosphate through third-degree burn eschar. Iran J Pharm Res 2013 Winter;12(1):3-8.
10. Arslan K, Karahan O, Okus A, et al. Comparison of topical zinc oxide and silver sulfadiazine in burn wounds: an experimental study. Ulus Travma Acil Cerrahi Derg 2012 Sep;18(5):376-83. [DOI:10.5505/tjtes.2012.45381]
11. Lansdown AB, Mirastschijski U, Stubbs N, Scanlon E, Agren MS. Zinc in wound healing: theoretical, experimental, and clinical aspects. Wound Repair Regen 2007 Jan-Feb;15(1):2-16. [DOI:10.1111/j.1524-475X.2006.00179.x]
12. Agren MS, Chvapil M, Franzen L. Enhancement of re-epithelialization with topical zinc oxide in porcine partial-thickness wounds. J Surg Res 1991 Feb;50(2):101-5. [DOI:10.1016/0022-4804(91)90230-J]
13. Hsu DZ, Su SB, Chien SP, et al. Effect of sesame oil on oxidative-stress-associated renal injury in endotoxemic rats: involvement of nitric oxide and proinflammatory cytokines. Shock 2005 Sep;24(3):276-80. [DOI:10.1097/01.shk.0000172366.73881.c7]
14. Rangkadilok N, Pholphana N, Mahidol C, et al. Variation of sesamin, sesamolin and tocopherols in sesame (Sesamum indicum L.) seeds and oil products in Thailand. Food Chem 2010 2010/10/01/;122(3):724-30. [DOI:10.1016/j.foodchem.2010.03.044]
15. Afroz M, Zihad sMN, Uddin S, et al. Antiinflammatory activity of Sesame oil and further confirmation by chemical profiling and molecular docking. Phytother Res 2019 08/01;33(10):1-24. [DOI:10.1002/ptr.6428]
16. Kiran K, Asad M. Wound healing activity of Sesamum indicum L seed and oil in rats. Indian J Exp Biol 2008 Nov;46(11):777-82.
17. Pan SC. Burn blister fluids in the neovascularization stage of burn wound healing: A comparison between superficial and deep partial-thickness burn wounds. Burns Trauma 2013;1(1):27-31. [DOI:10.4103/2321-3868.113332]
18. Strudwick X, Cowin A. The Role of the Inflammatory Response in Burn Injury. In: Kartal S, Bayramgurler D, editors. Hot Topics in Burn Injuries: IntechOpen; 2018. [DOI:10.5772/intechopen.71330]
19. Parihar A, Parihar MS, Milner S, Bhat S. Oxidative stress and anti-oxidative mobilization in burn injury. Burns 2008 Feb;34(1):6-17. [DOI:10.1016/j.burns.2007.04.009]
20. Kang NJ, Han SC, Yoon SH, et al. Cinnamomum camphora leaves alleviate allergic skin inflammatory responses in vitro and in vivo. Toxicol Res 2019 Jul;35(3):279-85. [DOI:10.5487/TR.2019.35.3.279]
21. Nilius B, Owsianik G, Voets T, Peters JA. Transient receptor potential cation channels in disease. Physiol Rev 2007 Jan;87(1):165-217. [DOI:10.1152/physrev.00021.2006]
22. Xu H, Blair NT, Clapham DE. Camphor activates and strongly desensitizes the transient receptor potential vanilloid subtype 1 channel in a vanilloid-independent mechanism. J Neurosci 2005 Sep 28;25(39):8924-37. [DOI:10.1523/JNEUROSCI.2574-05.2005]
23. Ragucci KR, Trangmar PR, Bigby JG, Detar TD. Camphor ingestion in a 10-year-old male. South Med J 2007 Feb;100(2):204-7. [DOI:10.1097/01.smj.0000254584.20463.31]
24. Noronha C, Almeida A. Local burn treatment - topical antimicrobial agents. Ann Burns Fire Disasters 2000;13(4).
25. Vardanyan RS, Hruby VJ. 33 - Antimicrobial Drugs. In: Vardanyan RS, Hruby VJ, editors. Synthesis of Essential Drugs. Amsterdam: Elsevier; 2006. P. 499-523. [DOI:10.1016/B978-044452166-8/50033-9]
26. Bankole MA, Shittu LAJ, Ahmed TA, et al. Synergistic antimicrobial activities of phytoestrogens in crude extracts of two sesame species against some common pathogenic microorganisms. Afr J Tradit Complem 2007;4(4):427-33. [DOI:10.4314/ajtcam.v4i4.31237]
27. Akiyama H, Yamasaki O, Kanzaki H, Tada J, Arata J. Effects of zinc oxide on the attachment of Staphylococcus aureus strains. J Dermatol Sci 1998 May;17(1):67-74. [DOI:10.1016/S0923-1811(97)00070-4]
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
