مجله جهانی جراحی پلاستیک
مجله جهانی جراحی پلاستیک
پنجشنبه 7 خرداد 1405
[Archive]
چکیده: (33 مشاهده)
Background: Using natural compounds can overcome the disruption of traditional sutures and the problems of tissue adhesives in the wound healing process, the biomedical market has seen many effective skin products but many of them are still have limited. We aimed to use both herbal essential oil and gels to fabricate and study a new oleoresin essential oil of wild pistachio tree Tragacanth resin xerogel-like Bio-adhesive for skin surgery. Its low stiffness, scaffold-based matrix due to the gel part it can facilitate wound healing.
Methods: Different concentrations of resin 6-9 w/v and essential oils 0.2 -1 w/v were blended according to the response surface methodology using the central composite design. The attachments were fabricated using the freeze-drying technique. These were assessed physically and biologically cell viability, cell attachment, SEM, FTIR techniques and in vivo a mouse incision injection model.
Results: Tragacanth resin is an adhesive agent glue. The gel part could affect the physical properties of attachments including FTIR, the strong peak at 1638.57 cm-1 and Particle size including SEM Mean ±Std Dev; 47 ±0.89 µm. Also, it demonstrated no cytotoxicity towards H-Fib cells, 80% cell viability with good attachment, and cell concentration justified by the gel content. It showed good in vivo biocompatibility.
Conclusion: Fabricated Bio-adhesive gel-like attached with essential oil of wild pistachio content can be a good candidate for regeneration-skin-based surgical purposes. However more in vitro and in vivo revisions are mandatory to adjust the herbal essential oil resin ratio.
Methods: Different concentrations of resin 6-9 w/v and essential oils 0.2 -1 w/v were blended according to the response surface methodology using the central composite design. The attachments were fabricated using the freeze-drying technique. These were assessed physically and biologically cell viability, cell attachment, SEM, FTIR techniques and in vivo a mouse incision injection model.
Results: Tragacanth resin is an adhesive agent glue. The gel part could affect the physical properties of attachments including FTIR, the strong peak at 1638.57 cm-1 and Particle size including SEM Mean ±Std Dev; 47 ±0.89 µm. Also, it demonstrated no cytotoxicity towards H-Fib cells, 80% cell viability with good attachment, and cell concentration justified by the gel content. It showed good in vivo biocompatibility.
Conclusion: Fabricated Bio-adhesive gel-like attached with essential oil of wild pistachio content can be a good candidate for regeneration-skin-based surgical purposes. However more in vitro and in vivo revisions are mandatory to adjust the herbal essential oil resin ratio.
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