The Effect of Oliveria Decumbens and Pelargonium Graveolens on Healing of Infected Skin Wounds in Mice

Mahboubi, Mohaddese; Feizabadi, Mohammad Mehdi; Khamechian, Tahereh; Kazempour, Nastaran; Razavi Zadeh, Mohsen; Sasani, Farhang; Bekhradi, Mohsen

Volume 5, Issue 3 (2016) WJPS 2016, 5(3): 259-264 | Back to browse issues page

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Mahboubi M, Feizabadi M M, Khamechian T, Kazempour N, Razavi Zadeh M, Sasani F et al . The Effect of Oliveria Decumbens and Pelargonium Graveolens on Healing of Infected Skin Wounds in Mice . WJPS 2016; 5 (3) :259-264
URL: http://wjps.ir/article-1-204-en.html

The Effect of Oliveria Decumbens and Pelargonium Graveolens on Healing of Infected Skin Wounds in Mice

Mohaddese Mahboubi ^*¹

, Mohammad Mehdi Feizabadi²

, Tahereh Khamechian³

, Nastaran Kazempour⁴

, Mohsen Razavi Zadeh⁵

, Farhang Sasani⁶

, Mohsen Bekhradi⁷

1- Microbiology Department, Medicinal Plant Research Center of Barij, Kashan, Iran , mahboubi1357@yahoo.com
2- Department of Microbiology, School of Medicine, Tehran University of Medical Science, Tehran, Iran
3- Department of Pathology, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, Iran
4- Microbiology Department, Medicinal Plant Research Center of Barij, Kashan, Iran
5- Gastroenterology Department, Beheshti Hospital, Kashan University of Medical Sciences, Kashan, Iran
6- Department of Pathology, Faculty of Veterinary Medicine, Tehran University, Tehran, Iran
7- Formulation Department, Medicinal Plant Research Center of Barij, Kashan, Iran

Abstract: (6063 Views)

BACKGROUND

Staphylococcus aureus is one of the most causative organisms in the skin wound infections. Development of resistant S. aureus to current treatments in individuals with low immunity is a global concern. The aim of this study was to evaluate the efficacy of herbal formulation against skin wound infection.

METHODS

The efficacy of herbal formulation containing Oliveria decumbens and Pelargonium graveolens essential oils was evaluated in comparison to mupirocin against Methicillin Resistant S. aureus (MRSA) related skin wound infection in mice animal model.

RESULTS

The herbal cream and mupirocin decreased the log CFU by 2.5±0.26 and 2.46±0.32, respectively, while the log CFU of S. aureus from wound skin were 5.9±0.26 and 5.65±0.23 for placebo and control groups, respectively. Moreover, the histological examinations showed that this cream improved the wound healing and increased the collagen deposition and wound contraction.

CONCLUSION

This natural new formulation with O. decumbens and P. graveolens essential oils could be recommended as a new candidate for wound healing.

Keywords: Oliveria decumbens, Pelargonium graveolens, Healing, Infected wound, Mouse

Full-Text [PDF 591 kb] (3063 Downloads)

Type of Study: Original Article | Subject: General
ePublished: 2016/08/21