Volume 3, Issue 1 (2014)                   WJPS 2014, 3(1): 29-34 | Back to browse issues page

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Akhoondinasab M R, Akhoondinasab M, Saberi M. Comparison of Healing Effect of Aloe Vera Extract and Silver Sulfadiazine in Burn Injuries in Experimental Rat Model. WJPS 2014; 3 (1) :29-34
URL: http://wjps.ir/article-1-102-en.html
Comparison of Healing Effect of Aloe Vera Extract and Silver Sulfadiazine in Burn Injuries in Experimental Rat Model
Mohammad Reza Akhoondinasab 1, Motahhare Akhoondinasab2 , Mohsen Saberi3
1- Faculty of Plastic and Reconstructive Surgery, Burn Research Center, Iran University of Medical Sciences, Tehran, Iran , akhoondinasab@yahoo.com
2- Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
3- Medicine, Quran and Hadith Research Center, Department of Community Medicine, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran
Abstract:   (9538 Views)
BACKGROUND Wound healing is widely discussed in the medical literature. This study compared the healing effect of aloe vera extract and silver sulfadiazine in burn injuries in experimental rat model. METHODS Sixteen rats were randomly assigned to one of two groups, each group 8 rats. A deep second-degree burn on the lower back and 3rd degree burn on upper back of each rat were created with a standard burning procedure. Burns were dressed daily with aloe vera extract in group 2 and silver sulfadiazine in group 1. Response to treatment was assessed by digital photography during treatment until day 32. Histological parameters (PMN, epithelialization, fibrosis and angiogenesis) were assessed after biopsy of scar at the end of research. RESULTS Wound healing was more visible in aloe vera group. Also the speed of healing in aloe vera group was better than silver sulfadiazine group. CONCLUSIONS Based on our findings, aloe vera can be a therapy of choice for burn injuries.
Keywords: Aloe vera; Silver sulfadiazine; Burn; Rat
Full-Text [PDF 597 kb]   (6543 Downloads)    
Type of Study: Original Article | Subject: Special
ePublished: 2013/12/9
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