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wjps 2015, 4(1): 16-22 Back to browse issues page
The Healing Effect of Scrophularia Striata on Experimental Burn Wounds Infected to Pseudomonas Aeruginosa in Rat
Nader Tanideh , Mohammad Hossein Haddadi , Mohammad Hossein Rokni-Hosseini , Masood Hossienzadeh , Davood Mehrabani , Kourosh Sayehmiri , Omid Koohi-Hossienabadi
Abstract:   (4137 Views)
BACKGROUND The cause of death in burn patients after 48 hours of hospitalization has been reported to be bacterial infections. Recently, due to the compounds accelerating the healing process and the intense reduction of treatment side effects, medicinal plants are used to cure burn wound infections. This study aims to investigate the medicinal effect of the ethanolic extract of Scrophularia striata on burn wound infection in in-vivo and in-vitro in comparison with silver sulfadiazine (SSD). METHODS One hundred and fifty male Sprague Dawley rats were divided into 3 equal groups. A hot plate of 1×1cm was used to create second degree burn wounds. The ethanolic extract of S. striata was provided through percolation method. Group 1 was treated with SSD, group 2 with S. striata, and group 3 was considered as control group. All animals were infected to Pseudomonas aeruginosa. On days 3, 7, 10, 14, and 21 after burn wound injury, the animals were euthanized and were evaluated histologically. The MIC and MBC were determined using the micro dilution method. RESULTS The rate of wound healing was significantly greater in S. striata group in comparison to SSD and control groups. CONCLUSION S. striata contains was shown to have anti-bacterial and wound healing effects while this effect was significantly more than SSD denoting to its use when needed for burn wounds infected to P. aeruginosa.
Keywords: Scrophularia striata, Wound, Healing, Silver sulfadiazine, Pseudomonas aeruginosa
Full-Text [PDF 1459 kb]   (1759 Downloads)    
Type of Study: Original Article | Subject: Special
Received: 2014/11/16 | Accepted: 2014/11/16 | Published: 2014/11/16
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Tanideh N, Haddadi M H, Rokni-Hosseini M H, Hossienzadeh M, Mehrabani D, Sayehmiri K et al . The Healing Effect of Scrophularia Striata on Experimental Burn Wounds Infected to Pseudomonas Aeruginosa in Rat. wjps. 2015; 4 (1) :16-22
URL: http://wjps.ir/article-1-128-en.html

Volume 4, Issue 1 (1-2015) Back to browse issues page
مجله جهانی جراحی پلاستیک World Journal of Plastic Surgery
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